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Texto: Nicole Robb | University of Oxford Department of Physics Home Study here Research Enterprise About us Contacts Alumni More... Students Departmental Policies Equality and Diversity Blogs The Beecroft Building Enter the terms you wish to search for. Department of Physics Contacts People Nicole Robb Nicole Robb Nicole Robb Visiting Lecturer Nicole.Robb@physics.ox.ac.uk About Teaching Research I completed a BSc. in Microbiology at Imperial College London before doing a D.Phil under the supervision of Prof. Ervin Fodor at the Sir William Dunn School of Pathology, University of Oxford, where I specialised in the field of influenza virology. In 2011 I joined the laboratory of Prof. Achillefs Kapanidis in Biological Physics, where I worked as a post-doctoral research associate, using single-molecule techniques to study how viruses and bacteria replicate. Following this I was awarded a Royal Society Fellowship to start my own group, using fluorescent microscopy techniques to visualise, study and detect RNA viruses at the single-molecule level. In 2020 I became an Assistant Professor at the University of Warwick, while maintaining a visiting lectureship at the University of Oxford. I teach regular virology seminars for second and third year medical students. The diverse grouping of RNA viruses includes multiple human, animal and plant pathogens; the diseases caused by these viruses result in substantial mortality in humans and have severe economic impact. My research focuses on the use of traditional biochemical and virology approaches, combined with novel single-molecule fluorescent spectroscopy techniques, to study RNA viruses and to develop methods for their diagnosis and treatment. My work can be divided into three categories: a) Using in-vitro single-molecule assays like FRET to investigate the conserved mechanisms of replication of RNA viruses.These techniques can be used to identify rate-limiting steps in replication that can be targeted with anti-viral inhibitors. b) Studying the morphology and cellular interactions of influenza viruses using super-resolution fluorescence microscopy, providing novel information on their size and structure, as well as the interactions between viruses and the infected cell which is vital to combating viral disease. c) Development of rapid and sensitive fluorescence-based diagnostic assays to identify RNA viruses in complex biological samples. These assays have the potential for medical impact as the advantages over traditional diagnostic tests include specificity, sensitivity, speed and ease-of-use. Visit my research group website Contact details Nicole RobbClarendon LaboratoryParks RoadOxfordOX1 3PU Telephone: 01865 (2)72357 My research Single Molecule Spectroscopy of Gene Machines Publications Rapid functionalisation and detection of viruses via a novel Ca2+-mediated virus-DNA interaction Scientific Reports Nature Research 9 (2019) 16219 N Robb, J Taylor, A Kent et al. Real-time analysis of single influenza virus replication complexes reveals large promoter-dependent diffe... Nucleic Acids Research Oxford University Press (OUP) (0) NC Robb, AJW te Velthuis, E Fodor et al. Coming together during viral assembly. Nature reviews. Microbiology 16 (2018) 721-721 C Hepp, NC Robb Publisher Correction: Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benc... Nature methods 15 (2018) 984-984 B Hellenkamp, S Schmid, O Doroshenko et al. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nature methods 15 (2018) 669-676 B Hellenkamp, S Schmid, O Doroshenko et al. Single-molecule analysis of the influenza virus replication initiation mechanism Biophysical Journal Biophysical Society 114 (2018) 246A-246A N Robb, AJW te Velthuis, E Fodor et al. Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes Nucleic Acids Research Oxford University Press 46 (2017) 677-688 D Duchi, K Gryte, NC Robb et al. Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter ... Nucleic Acids Research Oxford University Press (2016) NC Robb, AJW te Velthuis, R Wieneke et al. RNA polymerase pausing during initial transcription Molecular cell Cell Press 63 (2016) 939-950 D Duchi, DLV Bauer, L Fernandez et al. The role of the priming loop in influenza A virus RNA synthesis Nature Microbiology Nature (2016) A Te Velthuis, N Robb, AN Kapanidis et al. The role of the priming loop in influenza A virus RNA synthesis. Nature microbiology 1 (2016) 16029- AJW Te Velthuis, NC Robb, AN Kapanidis et al. Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.... Proceedings of the National Academy of Sciences of the United States of America 111 (2014) E3335-E3342 AI Tomescu, NC Robb, N Hengrung et al. The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneit... J Mol Biol 425 (2013) 875-885 NC Robb, T Cordes, LC Hwang et al. The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneit... Journal of Molecular Biology 425 (2013) 875-885 NC Robb, T Cordes, LC Hwang et al. Characterizing Influenza a RNA Polymerase - Promoter Interaction using Ensemble Fluorescence Spectroscopy... BIOPHYSICAL JOURNAL 104 (2013) 584A-584A AI Tomescu, NC Robb, N Hengrung et al. Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenical... PLoS Pathog 8 (2012) e1002998- HM Wise, EC Hutchinson, BW Jagger et al. Single-Molecule Studies of Transcription Initiation using a Vesicle Approach BIOPHYSICAL JOURNAL 102 (2012) 485A-485A DD Llumigusin, N Robb, K Gryte et al. The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein Journal of General Virology 93 (2012) 113-118 NC Robb, E Fodor The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein. The Journal of general virology 93 (2012) 113-118 NC Robb, E Fodor The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes. Journal of virology 85 (2011) 5228-5231 NC Robb, G Chase, K Bier et al. The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes Journal of Virology 85 (2011) 5228-5231 NC Robb, G Chase, K Bier et al. NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering... Journal of virology 84 (2010) 11323-11335 Z Wang, NC Robb, E Lenz et al. Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein. J Gen Virol 91 (2010) 2331-2340 NC Robb, D Jackson, FT Vreede et al. Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are cruc... Journal of virology 84 (2010) 7337-7345 W-H Chan, AK-L Ng, NC Robb et al. Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are cruc... Journal of Virology 84 (2010) 7337-7345 WH Chan, AKL Ng, NC Robb et al. RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell 140 (2010) 397-408 J Rehwinkel, CP Tan, D Goubau et al. NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering... Journal of Virology 84 (2010) 11323-11335 Z Wang, NC Robb, E Lenz et al. NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome Journal of General Virology 90 (2009) 1398-1407 NC Robb, M Smith, FT Vreede et al. NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. The Journal of general virology 90 (2009) 1398-1407 NC Robb, M Smith, FT Vreede et al. Contact search Department of Physics Contact Follow us Information for Information about Quick links   Clarendon Laboratory Parks Road Oxford OX1 3PU Tel: +44 (0)1865 272200 Find us Getting here Subdepartments Alumni Current Physics students Enterprise Outreach Prospective graduate students Prospective undergraduates Visitors Admissions procedures Health and Safety Fellowship opportunities Physics Aptitude Test Physics open days Physics research Work experience Contact search Departmental Policies Equality and Diversity IT Support Job opportunities Media Services Unit Nexus365 email © 2020 The University of Oxford Department of Physics  ·  Cookies and web privacy  ·  Accessibility Statement   Log in


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