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Texto: Tyler Group — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search Research Tyler Group Tyler Group 01865 282252 (fax 01865 282272) damian.tyler@dpag.ox.ac.uk Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy Metabolic images of the conversion of hyperpolarized pyruvate into bicarbonate and lactate in the normal and infarcted heart. A/F show standard proton images of the perfused heart, B/G show late gadolinium images highlighting the infarct area with a region of hypointensity, C/H show the distribution of the infused hyperpolarized pyruvate whilst D/I and E/J show the distribution of bicarbonate and lactate respectively. An area of reduced bicarbonate and enhanced lactate signal can be seen in the region of the infarct. Using metabolic imaging to transform our approach to disease detection and treatment Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) have long been used to monitor structure and function at repeated times and at stages of disease progression. However, the application of MRI/MRS for metabolic imaging has been limited by intrinsically low sensitivity. In standard MRI, the proton concentration in water compensates for low sensitivity; this is not true for low natural abundance magnetic nuclei, such as carbon (13 C). Hyperpolarization using the Dynamic Nuclear Polarization (DNP) technique, first explored and applied in solid-state physics, is a process that yields greater than 10,000-fold signal increases in MR-active nuclei. When used with MR spectroscopy, liquid-state hyperpolarized 13 C MR enables unprecedented real-time visualization of the biochemical mechanisms of normal and abnormal metabolism. This allows measurement of instantaneous rates of substrate uptake and enzymatic transformation in vivo, providing a sensitive measurement for the early stages of disease. The aim of our work is to utilize and further these developments to study initial rates of metabolism in the healthy and diseased heart. The majority of our work focuses on the assessment of rates of pyruvate metabolism through key metabolic enzymes (e.g. Pyruvate Dehydrogenase) and how they are altered in disease. Through technical developments, our work will also allow the study of other important metabolic molecules and the assessment of pH. Understanding of initial metabolic rates of key molecules will provide insight into disease identification, progression and treatment that will provide new information to the study of cardiac metabolism. Our team Damian Tyler Professor of Physiological Metabolism Vicky Ball Research Technician Dr Kerstin Nina Timm Visiting BHF Immediate Postdoctoral Basic Science Research Fellow Andrew Lewis Clinical Lecturer Jack Miller Novo Nordisk Postdoctoral Research Fellow Tony Zhou Postgraduate Student Andrew Tyler DPhil student Stephanie Anderson DPhil Student Andrew Apps Clinical research fellow & DPhil student Catriona Rooney DPhil Student Justin Lau Postdoctoral Research Fellow James Grist Postdoctoral Research Scientist Selected publications Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart. Journal article Ball DR. et al, (2014), Magn Reson Med, 71, 1663 - 1669 Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate. Journal article Ball DR. et al, (2013), NMR Biomed, 26, 1441 - 1450 Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics. Journal article Schroeder MA. et al, (2013), Proc Natl Acad Sci U S A, 110, E958 - E967 In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. Journal article Dodd MS. et al, (2012), Cardiovasc Res, 95, 69 - 76 The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. Journal article Schroeder MA. et al, (2012), Circ Cardiovasc Imaging, 5, 201 - 209 Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease. Journal article Schroeder MA. et al, (2011), Circulation, 124, 1580 - 1594 Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study. Journal article Atherton HJ. et al, (2011), Circulation, 123, 2552 - 2561 Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. Journal article Schroeder MA. et al, (2009), FASEB J, 23, 2529 - 2538 In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Journal article Schroeder MA. et al, (2008), Proc Natl Acad Sci U S A, 105, 12051 - 12056 © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat


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