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Title: Mahmod group — Radcliffe Department of Medicine
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Texto: Mahmod group — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search Research Mahmod group Mahmod group Cardiovascular Clinical Research Facility Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research Our expertise is in clinical trials, whereby we aim to discover novel treatments for improving the health of patients with cardiac diseases. We use cardiovascular magnetic resonance imaging (CMR) and spectroscopy techniques to improve our understanding of myocardial metabolism and function, and for early detection of cardiac abnormalities in cardiomyopathy, heart failure, valve disease and diabetes. We use cardiopulmonary exercise test to understand cardiovascular exercise physiology, by studying how oxygen and other nutrients are used by the heart during exercise. We work closely with multidisciplinary research teams including MR physicists, biomedical engineers and other cardiac imaging experts in the UK and elsewhere in the world. Our main current studies are The EMPA-Vision trial This multi-million pound, phase 3 clinical trial investigates a novel drug that could help failing hearts. This is the first trial to evaluate the effect of the diabetes medication empagliflozin on cardiac energy metabolism in patients with heart failure. The results of this trial combined with other ongoing multi-centre trials assessing clinical outcomes in patients with heart failure, could make empagliflozin a promising new treatment for patients with heart failure. Trial sponsored and funded by Boehringer Ingelheim Ox-FAST study This British Heart Foundation-funded pilot project is the first step in examining whether a drug that is already used to treat high fat levels in people could potentially improve heart function in aortic stenosis, one of the most common and serious heart valve diseases. In this study, we will try to reduce excessive heart fat by targeting it with a fat-busting, fibrate drug which we hope will improve the heart’s function and exercise capacity. If the concept behind it is proven, there is the potential to use fibrates as a new treatment for aortic stenosis, after larger trials. Our team Masliza Mahmod Associate Professor of Cardiovascular Medicine Moritz Hundertmark Clinical Research Fellow and DPhil Student Shveta Monga Clinical Research Fellow and DPhil student Betty Raman Hanan Lamlum Clinical Research Co-ordinator Selected publications A Hyperdynamic RV Is an Early Marker of Clinical Decompensation and Cardiac Recovery in Aortic Stenosis With Normal LV Ejection Fraction. Journal article Rigolli M. et al, (2019), JACC Cardiovasc Imaging, 12, 214 - 216 Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications. Journal article Raman B. et al, (2019), Eur Heart J Cardiovasc Imaging, 20, 157 - 167 collaborators (UK) Dr Pablo Lamata, King’s College London, UK Dr Sanjay Prasad, Royal Brompton and Harefield NHS Trust, UK Prof Mary Sheppard, St George’s, University of London, UK Prof Jules Griffin, University of Cambridge, UK Prof Vicente Grau, University of Oxford, UK collaborators (outside the UK) Prof Alistair Young, University of Auckland, New Zealand Dr James White, University of Calgary, Canada Dr Ntobeko Ntusi, Groote Schuur Hospital, Capetown, South Africa Dr Raymond Kwong, Havard Medical School, USA Prof Jean-Luc Balligand, Université catholique de Louvain, Belgium Dr Christopher Kramer, University of Virginia, USA Related research themes Cardiovascular Science Diabetes, Metabolism and Endocrinology Clinical Imaging Clinical Studies and Trials © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borl


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