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Title: Yara Alenazi — Radcliffe Department of Medicine
Description: BSc (Hons), MSc Yara Alenazi - DPhil Student
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Texto: Yara Alenazi — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Yara Alenazi Contact information Email yara.alenazi@worc.ox.ac.uk Colleges Worcester College Yara Alenazi BSc (Hons), MSc DPhil Student A broad range of diseases are characterized by inflammation driven by the expression of subsets of CC and CXC-class chemokines, and creates a robust network that has been difficult to therapeutically target using monovalent agents. The preferential binding of tick chemokine binding proteins (CKBPs) to limited subsets of CC or CXC chemokines, could provide a method to polyvalently but precisely target disease-relevant chemokines without unnecessarily affecting irrelevant chemokines, providing an advantage over viral and helminth CKBPs. My research focuses on identifying and characterising novel CKBP from tick saliva, using the 'Bug-to-Drug' approach. The availability of different tick CKBP that polyvalently target subsets of CC and CXC chemokines provides the opportunity to use them in combination to treat inflammatory diseases characterized by CC and CXC chemokine expression. The development of such combination therapeutics is however complicated by performance issues including risks and benefits of each individual agent in a combination. These considerations prompted us to explore the possibility that the two distinct classes of tick CKBPs could be fused into a single agent, creating what we have termed the 'two-warhead' CKBP, that binds subsets of both CC and CXC chemokines. My current research focuses look at characterising the 'two-warhead' CKBP we have engineered in the laboratory providing a biochemical and functional profile.  Websites BBC News: Tick saliva 'gold mine' blocks killer heart condition BBC News: Tick saliva 'gold mine' blocks killer heart condition British Heart Foundation (BHF) - How ticks are helping to cure heart disease How ticks are helping to cure heart disease From bug to drug: tick saliva could be key to treating heart disease From bug to drug: tick saliva could be key to treating heart disease © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda 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Cristina Di Genua Charlotte George Emily Georgiades Sahar Ghaffari Richard Gibbons Maria Giebler Deborah Gill Anne Gilligan Anna Gloyn Anna Gluck Anuj Goel Tomas Goncalves Claudia Gonzalez-Lopez Sarah Gooding Anne Goriely Matthew Gosden Stephen Gough Stephen Gough


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268 www.rdm.ox.ac.uk/people/edward-drydale
269 www.rdm.ox.ac.uk/people/yue-du
270 www.rdm.ox.ac.uk/people/claire-duff
271 www.rdm.ox.ac.uk/people/samuel-dunkley
272 www.rdm.ox.ac.uk/people/pamela-dyson
273 www.rdm.ox.ac.uk/people/james-early
274 www.rdm.ox.ac.uk/people/james-eaton
275 www.rdm.ox.ac.uk/people/carol-eaton
276 www.rdm.ox.ac.uk/people/laurienne-gardner
277 www.rdm.ox.ac.uk/people/christian-eggeling
278 www.rdm.ox.ac.uk/people/mehroz-ehsan
279 www.rdm.ox.ac.uk/people/jane-ellis
280 www.rdm.ox.ac.uk/people/hanif-esmail
281 www.rdm.ox.ac.uk/people/lise-estcourt
282 www.rdm.ox.ac.uk/people/rachel-etherington
283 www.rdm.ox.ac.uk/people/mark-evans
284 www.rdm.ox.ac.uk/people/tracey-evans
285 www.rdm.ox.ac.uk/people/martyn-ezra
286 www.rdm.ox.ac.uk/people/anne-farmer
287 www.rdm.ox.ac.uk/people/martin-farrall
288 www.rdm.ox.ac.uk/people/martin-fellermeyer
289 www.rdm.ox.ac.uk/people/candida-fenton
290 www.rdm.ox.ac.uk/people/david-ferguson
291 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
292 www.rdm.ox.ac.uk/people/vanessa-ferreira
293 www.rdm.ox.ac.uk/people/lucy-field
294 www.rdm.ox.ac.uk/people/alison-fletcher
295 www.rdm.ox.ac.uk/people/gary-ford
296 www.rdm.ox.ac.uk/people/nicholas-fordham
297 www.rdm.ox.ac.uk/people/helena-francis
298 www.rdm.ox.ac.uk/people/john-frankland
299 www.rdm.ox.ac.uk/people/rachel-franklin
300 www.rdm.ox.ac.uk/people/joe-frost
301 www.rdm.ox.ac.uk/people/xiaopeng-fu
302 www.rdm.ox.ac.uk/people/lars-fugger
303 www.rdm.ox.ac.uk/people/lars-fugger-1
304 www.rdm.ox.ac.uk/people/tudor-fulga
305 www.rdm.ox.ac.uk/people/kezia-gaitskell
306 www.rdm.ox.ac.uk/people/parag-gajendragadkar-1
307 www.rdm.ox.ac.uk/people/silvia-galiani
308 www.rdm.ox.ac.uk/people/toby-gamlen-1
309 www.rdm.ox.ac.uk/people/jonathan-gamwell
310 www.rdm.ox.ac.uk/people/wei-gan
311 www.rdm.ox.ac.uk/people/weigan
312 www.rdm.ox.ac.uk/people/syed-gardezi
313 www.rdm.ox.ac.uk/people/tina-garland
314 www.rdm.ox.ac.uk/people/katja-gehmlich
315 www.rdm.ox.ac.uk/people/cristina-di-genua
316 www.rdm.ox.ac.uk/people/charlotte-george
317 www.rdm.ox.ac.uk/people/emily-georgiades
318 www.rdm.ox.ac.uk/people/sahar-ghaffari
319 www.rdm.ox.ac.uk/people/richard-gibbons
320 www.rdm.ox.ac.uk/people/maria-giebler
321 www.rdm.ox.ac.uk/people/deborah-gill
322 www.rdm.ox.ac.uk/people/anne-gilligan
323 www.rdm.ox.ac.uk/people/anna-gloyn
324 www.rdm.ox.ac.uk/people/anna-gluck
325 www.rdm.ox.ac.uk/people/anuj-goel
326 www.rdm.ox.ac.uk/people/tomas-goncalves
327 www.rdm.ox.ac.uk/people/claudia-gonzalez-lopez
328 www.rdm.ox.ac.uk/people/sarah-gooding
329 www.rdm.ox.ac.uk/people/anne-goriely
330 www.rdm.ox.ac.uk/people/matthew-gosden
331 www.rdm.ox.ac.uk/people/stephen-gough
332 www.rdm.ox.ac.uk/people/stephen-gough-1



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