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Title: Tomasz Dobrzycki — Radcliffe Department of Medicine
Description: BSc (Hons) Tomasz Dobrzycki - DPhil Student
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Texto: Tomasz Dobrzycki — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Tomasz Dobrzycki Contact information Email tomasz.dobrzycki@msdtc.ox.ac.uk Telephone +44 (0)1865 222373 Website https://twitter.com/DobrzyckiTomasz Colleges Green Templeton College ORCID 0000-0002-7708-3188 Tomasz Dobrzycki BSc (Hons) DPhil Student I am a DPhil student in the research group of Prof Roger Patient, co-supervised by Dr Rui Monteiro, funded by the Wellcome Trust Chromosome and Developmental Biology programme . My research focuses on genetic controls of haematopoietic stem cells (HSCs) during embryonic development. We hope that thorough understanding of the molecular processes responsible for the generation of the HSCs in the embryo will allow their production for clinical applications. The HSCs, also known as blood stem cells, could be used in the future for treating blood disorders, such as immunodeficiencies or leukaemias. In my project, I use zebrafish as a model system to better understand the involvement of two particular genes, Gata2 and Lmo4, in the early stages of making the HSCs. By using CRISPR/Cas9 and TALEN technologies, I have generated mutant zebrafish lines to study the effects of depletion of Gata2 and Lmo4 in the haematopoietic tissues. I have also used Tol2 transgenesis to generate reporter lines for monitoring the spatial and temporal activity of Gata2. I complement these approaches with transient gene knock-downs with morpholino oligos or tissue-specific overexpression with DNA constructs. As my main analysis methods, I use in situ hybridization, qRT-PCR in FACS-sorted cells, live fluorescent imaging (widefield and confocal), RNA-seq and ATAC-seq. I also have expertise in molecular cloning and immunocytochemistry. Besides the research work, I am actively involved in public engagement and science communication. I write for the WIMM Blog and I participate in outreach events. My achievements in this field include the first prize in University of Oxford's Three-Minute Thesis Competition and second prize in the regional final of FameLab.  My contributions have been recognised with MRC WIMM Public Engagement Prize 2017 . Moreover, I have done statistics teaching for undergraduate Biochemistry students. I am also involved in Innovation Forum Oxford , an organisation linking academic research in healthcare and biotechnology with funders and policy makers to aid business development. Before coming to Oxford, I completed a BSc (Hons) in Genetics at the University of York. This degree included a yearlong research placement in the group of Christian Eckmann at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. Three minute thesis FameLab WIMM Blog entries The science behind the headlines Ever wondered where your blood comes from? Fishing for improved leukaemia treatments © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Veronica Alcolea Devesa Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes Vanessa Ferreira Lucy Field Alison Fletcher Gary Ford


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264 www.rdm.ox.ac.uk/people/kathleen-dolan
265 www.rdm.ox.ac.uk/people/hamid-dolatshad
266 www.rdm.ox.ac.uk/people/robert-friedrich-donat
267 www.rdm.ox.ac.uk/people/tao-dong
268 www.rdm.ox.ac.uk/people/patricia-douglas
269 www.rdm.ox.ac.uk/people/gillian-douglas
270 www.rdm.ox.ac.uk/people/damien-downes
271 www.rdm.ox.ac.uk/people/alexander-drakesmith
272 www.rdm.ox.ac.uk/people/roy-drissen
273 www.rdm.ox.ac.uk/people/edward-drydale
274 www.rdm.ox.ac.uk/people/yue-du
275 www.rdm.ox.ac.uk/people/claire-duff
276 www.rdm.ox.ac.uk/people/samuel-dunkley
277 www.rdm.ox.ac.uk/people/pamela-dyson
278 www.rdm.ox.ac.uk/people/james-early
279 www.rdm.ox.ac.uk/people/james-eaton
280 www.rdm.ox.ac.uk/people/carol-eaton
281 www.rdm.ox.ac.uk/people/laurienne-gardner
282 www.rdm.ox.ac.uk/people/christian-eggeling
283 www.rdm.ox.ac.uk/people/mehroz-ehsan
284 www.rdm.ox.ac.uk/people/jane-ellis
285 www.rdm.ox.ac.uk/people/hanif-esmail
286 www.rdm.ox.ac.uk/people/lise-estcourt
287 www.rdm.ox.ac.uk/people/rachel-etherington
288 www.rdm.ox.ac.uk/people/mark-evans
289 www.rdm.ox.ac.uk/people/tracey-evans
290 www.rdm.ox.ac.uk/people/martyn-ezra
291 www.rdm.ox.ac.uk/people/anne-farmer
292 www.rdm.ox.ac.uk/people/martin-farrall
293 www.rdm.ox.ac.uk/people/martin-fellermeyer
294 www.rdm.ox.ac.uk/people/candida-fenton
295 www.rdm.ox.ac.uk/people/david-ferguson
296 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
297 www.rdm.ox.ac.uk/people/vanessa-ferreira
298 www.rdm.ox.ac.uk/people/lucy-field
299 www.rdm.ox.ac.uk/people/alison-fletcher
300 www.rdm.ox.ac.uk/people/gary-ford



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