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Title: Tao Dong — Radcliffe Department of Medicine
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Texto: Tao Dong — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Tao Dong Contact information Email tao.dong@imm.ox.ac.uk PA Louise Fraser louise.fraser@ndm.ox.ac.uk Research groups Dong Group: Human T cell responses against Viruses & Cancer Colleges University College Websites MRC Human Immunology Unit Research Unit MRC Weatherall Institute of Molecular Medicine Research Institute CAMS Oxford Institute Research Institute Nuffield Department of Medicine Department University College Dong Profile College DPhil research opportunities Tao Dong Professor of Immunology Program Leader, MRC Human Immunology Unit Founding Director (Oxford), CAMS-Oxford joint International Centre for Translational Immunology Founding Director (Oxford), Chinese Academy of Medical Sciences Oxford Institute (COI) Anti-tumour and viral T cell response T he main objective of my group’s research is to focus on the functional aspects of the antigen specific T cells and studying the factors affecting T cells in controlling virus infection and cancer development. For important human infections, cancer development and the course of disease is influenced mainly by the T cell response - while a robust and appropriate T cell response is beneficial to the host, a weak or inappropriate response can be ineffective or even have a detrimental effect. Numerous factors influence the quality of the T cell response to viral infections, predominant among them being the microenvironment of the infection site, the type of cells infected and the variability of the virus. By understanding the key factors required for efficient viral control by the T cell response in a number of different viral infections and viral associated cancer,  Recent success of clinical trials that block inhibitory receptors is exciting, however, only some patients respond to the treatmentand the risk for causing autoimmune disease is high- largely due to its none-specific nature. My group is aim to uncover the diverse mechanisms exploited by evolving tumours that cause T cells to lose their ability to detect and eliminate cancer cells in specific patients, and to what extent these functions can be restored and how potential toxic effect could be controlled and exhaustion could be prevented. We also interested in studying the impact of IFTIM3 genetic variation on Influenza, and other virus infection, immune responses and disease outcome Key publications Self-maintaining CD103+ cancer-specific T cells are highly energetic with rapid cytotoxic and effector responses. Journal article Abd Hamid M. et al, (2019), Cancer Immunol Res Enriched HLA-E and CD94/NKG2A interaction limits antitumor CD8+ tumor-infiltrating T lymphocyte responses. Journal article Abd Hamid M. et al, (2019), Cancer Immunol Res A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer. Journal article Li X. et al, (2019), Front Oncol, 9 Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Journal article Zhang Y-H. et al, (2013), Nat Commun, 4 Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection. Journal article Makvandi-Nejad S. et al, (2018), J Infect Dis, 217, 257 - 262 Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. Journal article Lee LY-H. et al, (2008), J Clin Invest, 118, 3478 - 3490 Recent publications Self-maintaining CD103+ cancer-specific T cells are highly energetic with rapid cytotoxic and effector responses. Journal article Abd Hamid M. et al, (2019), Cancer Immunol Res Broadly inhibiting anti-neuraminidase monoclonal antibodies induced by trivalent influenza vaccine and H7N9 infection in humans. Journal article Rijal P. et al, (2019), J Virol Changes of CD8+T cell subsets before and after treatment of nasopharyngeal carcinoma Conference paper Fan P. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 392 - 392 Correlation of the T cell PD-1 level with clinical characteristics and short-term treatment efficacy in nasopharyngeal carcinoma patients Conference paper Hu Y. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 360 - 360 Enriched HLA-E and CD94/NKG2a interaction limits anti-tumor CD8(+) tumor-infiltrating T lymphocyte responses Conference paper Abd Hamid MHB. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 1252 - 1253 Expression of HLA restricted HPV16 E6 and E7 antigen-specific CTL in advanced cervical squamous cell carcinoma patients Conference paper Cai H. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 1025 - 1025 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Nicolas Bery Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai


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