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Title: Simon Davis — Radcliffe Department of Medicine
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Texto: Simon Davis — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Simon Davis Contact information Email simon.davis@ndm.ox.ac.uk Telephone +44 (0)1865 221336 Research groups Davis Group: T-cell Biology Group Colleges Corpus Christi College Websites MRC Human Immunology Unit Research Unit MRC Weatherall Institute of Molecular Medicine Research Institute Simon Davis BSc (Hons), PhD Professor of Molecular Immunology T-cell Biology Group My laboratory is striving to understand how lymphocyte receptors are triggered, including the immune checkpoints. My PhD studies on Dictyostelium developmental biochemistry, also at Flinders, were supervised by John Wheldrake. It had been John who suggested, in one of his undergraduate classes, that all biochemistry students should read 'The Double Helix' by JD Watson. I read it and learnt two things: the thrill of discovery and that, when it really counts, it's not about where you're from but simply a matter of how good your ideas are versus the next person's. Under John's influence I developed an abiding interest in the cell surface and became particularly impressed by the pioneering work of Alan Williams and Neil Barclay on the T-cell surface at the UK Medical Research Council (MRC) Cellular Immunology Unit in Oxford. During a brief stint in California at UC San Diego as a visiting student in the laboratories of Hud Freeze and Ajit Varki, I became aware of the power of molecular biological techniques and the need to do medically-oriented research as a long-term career strategy.  In 1987 I secured a post-doctoral position in Alan William's laboratory and thereafter was able to focus on T-cell surface biology myself. Neil had begun introducing into the laboratory approaches for the production of large amounts of high-quality protein for structural and functional studies, and I was the first beneficiary of this. Collaborations with Shinji Ikemizu, Yvonne Jones, Dave Stuart and, in particular, Anton van der Merwe, were subsequently critical to our work. In 1995 I established my own laboratory in what is now the Radcliffe Department of Medicine, and I am now based at the MRC Weatherall Institute of Molecular Medicine, which is led by Doug Higgs. I am also a member of the MRC Human Immunology Unit, directed by Vincenzo Cerundolo. Recent publications The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale. Journal article Kulenkampff K. et al, (2020), Biophys J Inside-out mechanisms of CD6 signaling: cytoplasmic and extracellular interactions impact on T cell activation Conference paper Santos RF. et al, (2019), EUROPEAN JOURNAL OF IMMUNOLOGY, 49, 346 - 347 Investigation into how T cells trigger on various surfaces Conference paper Dam T. et al, (2019), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, S190 - S190 Single cell measurements of protein affinity in contacting cells Conference paper Chouliara M. et al, (2019), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, S190 - S190 The Interplay of Immune Cell Proteins Affects the Orientation, Organisation and Affinity within a Cell -Cell Conference paper Junghans V. et al, (2019), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, S191 - S191 More publications ORCID 0000-0002-2280-1170 © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Greig Dougall Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early


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260 www.rdm.ox.ac.uk/people/geoffrey-denwood
261 www.rdm.ox.ac.uk/people/michael-desborough
262 www.rdm.ox.ac.uk/people/matthew-dickinson
263 www.rdm.ox.ac.uk/people/marina-diotallevi
264 www.rdm.ox.ac.uk/people/tomasz-dobrzycki
265 www.rdm.ox.ac.uk/people/cameron-dockerill
266 www.rdm.ox.ac.uk/people/michael-dodd
267 www.rdm.ox.ac.uk/people/kathleen-dolan
268 www.rdm.ox.ac.uk/people/hamid-dolatshad
269 www.rdm.ox.ac.uk/people/robert-friedrich-donat
270 www.rdm.ox.ac.uk/people/tao-dong
271 www.rdm.ox.ac.uk/people/greig-dougall
272 www.rdm.ox.ac.uk/people/patricia-douglas
273 www.rdm.ox.ac.uk/people/gillian-douglas
274 www.rdm.ox.ac.uk/people/damien-downes
275 www.rdm.ox.ac.uk/people/alexander-drakesmith
276 www.rdm.ox.ac.uk/people/roy-drissen
277 www.rdm.ox.ac.uk/people/edward-drydale
278 www.rdm.ox.ac.uk/people/yue-du
279 www.rdm.ox.ac.uk/people/claire-duff
280 www.rdm.ox.ac.uk/people/samuel-dunkley
281 www.rdm.ox.ac.uk/people/pamela-dyson
282 www.rdm.ox.ac.uk/people/james-early



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