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Title: Simon Davis — Radcliffe Department of Medicine
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Texto: Simon Davis — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Simon Davis Contact information Email simon.davis@ndm.ox.ac.uk Telephone +44 (0)1865 221336 Research groups Davis Group: T-cell Biology Group Colleges Corpus Christi College Websites MRC Human Immunology Unit Research Unit MRC Weatherall Institute of Molecular Medicine Research Institute Simon Davis BSc (Hons), PhD Professor of Molecular Immunology T-cell Biology Group My laboratory is striving to understand how lymphocyte receptors are triggered, including the immune checkpoints. My PhD studies on Dictyostelium developmental biochemistry, also at Flinders, were supervised by John Wheldrake. It had been John who suggested, in one of his undergraduate classes, that all biochemistry students should read 'The Double Helix' by JD Watson. I read it and learnt two things: the thrill of discovery and that, when it really counts, it's not about where you're from but simply a matter of how good your ideas are versus the next person's. Under John's influence I developed an abiding interest in the cell surface and became particularly impressed by the pioneering work of Alan Williams and Neil Barclay on the T-cell surface at the UK Medical Research Council (MRC) Cellular Immunology Unit in Oxford. During a brief stint in California at UC San Diego as a visiting student in the laboratories of Hud Freeze and Ajit Varki, I became aware of the power of molecular biological techniques and the need to do medically-oriented research as a long-term career strategy.  In 1987 I secured a post-doctoral position in Alan William's laboratory and thereafter was able to focus on T-cell surface biology myself. Neil had begun introducing into the laboratory approaches for the production of large amounts of high-quality protein for structural and functional studies, and I was the first beneficiary of this. Collaborations with Shinji Ikemizu, Yvonne Jones, Dave Stuart and, in particular, Anton van der Merwe, were subsequently critical to our work. In 1995 I established my own laboratory in what is now the Radcliffe Department of Medicine, and I am now based at the MRC Weatherall Institute of Molecular Medicine, which is led by Doug Higgs. I am also a member of the MRC Human Immunology Unit, directed by Vincenzo Cerundolo. Recent publications A cell topography-based mechanism for ligand discrimination by the T cell receptor. Journal article Fernandes RA. et al, (2019), Proc Natl Acad Sci U S A CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity. Journal article Felce JH. et al, (2018), Sci Signal, 11 LAG-3: a very singular immune checkpoint. Journal article Lui Y. and Davis SJ., (2018), Nat Immunol, 19, 1278 - 1279 Capturing resting T cells: the perils of PLL. Journal article Santos AM. et al, (2018), Nat Immunol, 19, 203 - 205 Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations. Journal article Felce JH. et al, (2018), Trends Pharmacol Sci, 39, 96 - 108 More publications ORCID 0000-0002-2280-1170 © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Nicolas Bery Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Veronica Alcolea Devesa Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes


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264 www.rdm.ox.ac.uk/people/patricia-douglas
265 www.rdm.ox.ac.uk/people/gillian-douglas
266 www.rdm.ox.ac.uk/people/damien-downes
267 www.rdm.ox.ac.uk/people/alexander-drakesmith
268 www.rdm.ox.ac.uk/people/roy-drissen
269 www.rdm.ox.ac.uk/people/edward-drydale
270 www.rdm.ox.ac.uk/people/yue-du
271 www.rdm.ox.ac.uk/people/claire-duff
272 www.rdm.ox.ac.uk/people/samuel-dunkley
273 www.rdm.ox.ac.uk/people/pamela-dyson
274 www.rdm.ox.ac.uk/people/james-early
275 www.rdm.ox.ac.uk/people/james-eaton
276 www.rdm.ox.ac.uk/people/carol-eaton
277 www.rdm.ox.ac.uk/people/laurienne-gardner
278 www.rdm.ox.ac.uk/people/christian-eggeling
279 www.rdm.ox.ac.uk/people/mehroz-ehsan
280 www.rdm.ox.ac.uk/people/jane-ellis
281 www.rdm.ox.ac.uk/people/hanif-esmail
282 www.rdm.ox.ac.uk/people/lise-estcourt
283 www.rdm.ox.ac.uk/people/rachel-etherington
284 www.rdm.ox.ac.uk/people/mark-evans
285 www.rdm.ox.ac.uk/people/tracey-evans
286 www.rdm.ox.ac.uk/people/martyn-ezra
287 www.rdm.ox.ac.uk/people/anne-farmer
288 www.rdm.ox.ac.uk/people/martin-farrall
289 www.rdm.ox.ac.uk/people/martin-fellermeyer
290 www.rdm.ox.ac.uk/people/candida-fenton
291 www.rdm.ox.ac.uk/people/david-ferguson
292 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes



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