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Title: Shoumo Bhattacharya — Radcliffe Department of Medicine
Description: Shoumo Bhattacharya - British Heart Foundation Professor of Cardiovascular Medicine
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Texto: Shoumo Bhattacharya — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Shoumo Bhattacharya Contact information Email sbhattac@well.ox.ac.uk Telephone +44 (0)1865 287771 Research groups Bhattacharya Group: Developing novel therapeutics for inflammatory diseases Colleges Green Templeton College Websites British Heart Foundation Funder In the news Two-warhead evasins From bug to drug: tick saliva could be key to treating heart disease BBC News: Tick saliva 'gold mine' blocks killer heart condition DPhil research opportunities Shoumo Bhattacharya British Heart Foundation Professor of Cardiovascular Medicine Honorary Consultant Cardiologist Shoumo Bhattacharya is Professor of Cardiovascular Medicine in the RDM Division of Cardiovascular Medicine at the University of Oxford and is based at the Wellcome Trust Centre for Human Genetics.  He read medicine at the All India Institute of Medical Sciences in New Delhi, and trained in cardiology at Northwick Park and Hammersmith Hospitals in London, where he was also a MRC Training Fellow with James Scott working on RNA editing.  He followed this with BHF and NIH Fellowships at the Dana-Farber Cancer Institute with David Livingston working on transcription factor protein interactions. He was  a Wellcome Trust Senior Fellow at Oxford from 1998 to 2008, working on the transcriptional control of heart development, and their role in left-right patterning. He was elected Fellow of the Royal College of Physicians in 2003, awarded the Graham Bull Prize from the Royal College of Physicians in 2005, elected Fellow of the Academy of Medical Sciences in 2006. He was awarded a BHF Chair in 2009, and elected to a statutory Professorship at the University of Oxford in 2010. His primary role as BHF Chair has been the development of novel therapeutics and targets. The major focus of his lab is now the development of anti-inflammatory peptide therapeutics isolated from tick saliva that may have applications to myocarditis, post-myocardial infarction injury and myocardial fibrosis Key publications Using evasins to target the chemokine network in inflammation. Journal article Bhattacharya S. and Kawamura A., (2020), Adv Protein Chem Struct Biol, 119, 1 - 38 Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines Journal article Bhusal RP. et al, (2019), Trends in Biochemical Sciences A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Journal article Lee AW. et al, (2019), J Biol Chem The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins. Journal article Eaton JRO. et al, (2018), J Biol Chem, 293, 6134 - 6146 Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Journal article Alenazi Y. et al, (2018), Sci Rep, 8 Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities. Journal article Singh K. et al, (2017), Sci Rep, 7 VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Journal article Szumska D. et al, (2008), Genes Dev, 22, 1465 - 1477 Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Journal article Bamforth SD. et al, (2001), Nat Genet, 29, 469 - 474 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Journal article Bamforth SD. et al, (2004), Nat Genet, 36, 1189 - 1196 Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Journal article Bhattacharya S. et al, (1999), Genes Dev, 13, 64 - 75 Recent publications Using evasins to target the chemokine network in inflammation. Journal article Bhattacharya S. and Kawamura A., (2020), Adv Protein Chem Struct Biol, 119, 1 - 38 Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines Journal article Bhusal RP. et al, (2019), Trends in Biochemical Sciences A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Journal article Lee AW. et al, (2019), J Biol Chem Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Journal article Gao R. et al, (2019), Cell Res, 29, 486 - 501 Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. Journal article Gorman KM. et al, (2019), Am J Hum Genet, 104, 948 - 956 IDENTIFICATION OF THE MAJOR GENETIC CONTRIBUTORS TO TETRALOGY OF FALLOT Conference paper Page DJ. et al, (2019), HEART, 105, A182 - A183 Biowire Model of Interstitial and Focal Cardiac Fibrosis Journal article Wang EY. et al, (2019), ACS Central Science Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation. Journal article Bailey J. et al, (2018), Sci Rep, 8 A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Journal article Dykes IM. et al, (2018), Sci Rep, 8 Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Journal article Alenazi Y. et al, (2018), Sci Rep, 8 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard


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