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Title: Roy Drissen — Radcliffe Department of Medicine
Description: PhD Roy Drissen - Postdoctoral Researcher
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Texto: Roy Drissen — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Roy Drissen Contact information Email roy.drissen@imm.ox.ac.uk Research groups Nerlov Group: Hematopoietic Stem Cell Genetics Roy Drissen PhD Postdoctoral Researcher My research focuses on mouse and human hematopoiesis. The hematopoietic stem cell gives rise to all different blood cell types. In this process, intermediate progenitor cells derive from the stem cell that gradually loose lineage potential while differentiating towards one specific cell type. I am characterising various progenitors. This work leads towards improved models for hematopoietic hierarchies. These models are imperative for studying aspects of hematopoiesis, such as the mechanisms that are involved in lineage decisions and characterising cells of origin in hematopoietic malignancies. I am specifically interested in progenitors leading towards myeloid cell types, which consists of neutrophils, macrophages, eosinophils, basophils and mast cells. With single cell technologies, we have shown that these myeloid cell types are produced via two independent pathways. In particular the finding of a separate pathway that produces eosinophils, basophils and mast cells gives a unique opportunity to study myeloid malignancies that involve these cells, such as systemic mastocytosis and idiopathic eosinophilia. Since my PhD at the Erasmus MC in Rotterdam, the Netherlands (1999-2005), followed by a first postdoc position at the WIMM (2005-2009), I have had an interest in the control and effect of transcription factors in hematopoiesis. My earlier work involved erythropoiesis, and shifted towards myelopoiesis when I started my position at the Centre for Regenerative Medicine in Edinburgh (2009-2012). Now back at the WIMM, I continue working on normal hematopoieisis, translating the findings in the mouse to human, with the goal to study malignant human myelopoiesis. Recent publications Identification of two distinct pathways of human myelopoiesis. Journal article Drissen R. et al, (2019), Sci Immunol, 4 Hematopoietic Lineage Diversification, Simplified. Journal article Drissen R. and Nerlov C., (2016), Cell Stem Cell, 19, 148 - 150 Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing. Journal article Drissen R. et al, (2016), Nat Immunol, 17, 666 - 676 Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression. Journal article Drissen R. et al, (2010), Blood, 115, 3463 - 3471 A hanging drop culture method to study terminal erythroid differentiation Journal article Gutiérrez L. et al, (2005), Experimental Hematology, 33, 1083 - 1091 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Greig Dougall Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Oliver Featherstone Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes Vanessa Ferreira Lucy Field Alison Fletcher Gary Ford Nicholas Fordham Helena Francis John Frankland Rachel Franklin Joe Frost Xiaopeng Fu


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264 www.rdm.ox.ac.uk/people/kathleen-dolan
265 www.rdm.ox.ac.uk/people/hamid-dolatshad
266 www.rdm.ox.ac.uk/people/robert-friedrich-donat
267 www.rdm.ox.ac.uk/people/tao-dong
268 www.rdm.ox.ac.uk/people/greig-dougall
269 www.rdm.ox.ac.uk/people/patricia-douglas
270 www.rdm.ox.ac.uk/people/gillian-douglas
271 www.rdm.ox.ac.uk/people/damien-downes
272 www.rdm.ox.ac.uk/people/alexander-drakesmith
273 www.rdm.ox.ac.uk/people/roy-drissen
274 www.rdm.ox.ac.uk/people/edward-drydale
275 www.rdm.ox.ac.uk/people/yue-du
276 www.rdm.ox.ac.uk/people/claire-duff
277 www.rdm.ox.ac.uk/people/samuel-dunkley
278 www.rdm.ox.ac.uk/people/pamela-dyson
279 www.rdm.ox.ac.uk/people/james-early
280 www.rdm.ox.ac.uk/people/james-eaton
281 www.rdm.ox.ac.uk/people/carol-eaton
282 www.rdm.ox.ac.uk/people/laurienne-gardner
283 www.rdm.ox.ac.uk/people/christian-eggeling
284 www.rdm.ox.ac.uk/people/mehroz-ehsan
285 www.rdm.ox.ac.uk/people/jane-ellis
286 www.rdm.ox.ac.uk/people/hanif-esmail
287 www.rdm.ox.ac.uk/people/lise-estcourt
288 www.rdm.ox.ac.uk/people/rachel-etherington
289 www.rdm.ox.ac.uk/people/mark-evans
290 www.rdm.ox.ac.uk/people/tracey-evans
291 www.rdm.ox.ac.uk/people/martyn-ezra
292 www.rdm.ox.ac.uk/people/anne-farmer
293 www.rdm.ox.ac.uk/people/martin-farrall
294 www.rdm.ox.ac.uk/people/oliver-featherstone
295 www.rdm.ox.ac.uk/people/martin-fellermeyer
296 www.rdm.ox.ac.uk/people/candida-fenton
297 www.rdm.ox.ac.uk/people/david-ferguson
298 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
299 www.rdm.ox.ac.uk/people/vanessa-ferreira
300 www.rdm.ox.ac.uk/people/lucy-field
301 www.rdm.ox.ac.uk/people/alison-fletcher
302 www.rdm.ox.ac.uk/people/gary-ford
303 www.rdm.ox.ac.uk/people/nicholas-fordham
304 www.rdm.ox.ac.uk/people/helena-francis
305 www.rdm.ox.ac.uk/people/john-frankland
306 www.rdm.ox.ac.uk/people/rachel-franklin
307 www.rdm.ox.ac.uk/people/joe-frost
308 www.rdm.ox.ac.uk/people/xiaopeng-fu



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