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Title: Nicholas Blockley — Radcliffe Department of Medicine
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Texto: Nicholas Blockley — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Nicholas Blockley Contact information Email nicholas.blockley@ndcn.ox.ac.uk Telephone +44 (0) 1865 610476 Website http://www.twitter.com/nicblockley Funded by Research groups FMRI Physiology Websites Matthew Cherukara Profile Collaborators Cardiff University Brain Research Imaging Centre (CUBRIC) , Cardiff University Centre for Functional MRI , University of California San Diego Hotchkiss Brain Institute , University of Calgary Nicholas Blockley University Research Lecturer EPSRC Early Career Fellow Head of FMRI Physiology Research Summary The focus of my research is the development of new techniques to non-invasively image the function of the brain using MRI (Magnetic Resonance Imaging). I specialise in the measurement of aspects of brain physiology that are typically difficult to acquire using any other method. For example, my current EPSRC fellowship was awarded to develop new technologies for measuring oxygen metabolism in the human brain. Conventionally such measurements are performed using PET (Positron Emission Tomography) resulting in exposure to ionising radiation and long acquisition times. Even more importantly the equipment to perform these PET measurements is poorly available in the UK. In contrast 3T MRI is widely available in the NHS. Currently my team are collaborating with clinical colleagues to demonstrate the potential of these techniques in acute stroke, traumatic brain injury and brain tumours. Development of these new techniques is dependent on gaining a better understanding of the interaction between brain physiology and the MRI signal. This is achieved by developing sophisticated simulation tools to better understand sources of systematic error. Isolating specific aspects of physiology is achieved by sensitising the MRI signal using custom pulse sequences and tightly controlled respiratory stimuli. In the case of the former, I have developed a new asymmetric spin echo (ASE) pulse sequence to measure the reversible transverse relaxation rate R2 ′ (GESEPI-ASE) , which underpins our technique for measuring resting oxygen metabolism (streamlined-qBOLD). In the case of the latter, I have developed novel shaped respiratory stimuli to produce a rapid protocol for measuring vascular reactivity and provide new information about regional variations in blood arrival time (rapid cerebrovascular reactivity mapping). Recent publications Prospects for investigating brain oxygenation in acute stroke: Experience with a non-contrast quantitative BOLD based approach. Journal article Stone AJ. et al, (2019), Hum Brain Mapp, 40, 2853 - 2866 The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging. Journal article Seiler A. et al, (2019), J Cereb Blood Flow Metab, 39, 454 - 465 Multiparametric measurement of cerebral physiology using calibrated fMRI. Journal article Bright MG. et al, (2019), Neuroimage, 187, 128 - 144 Gas-free calibrated fMRI with a correction for vessel-size sensitivity. Journal article Berman AJL. et al, (2018), Neuroimage, 169, 176 - 188 Rapid cerebrovascular reactivity mapping: Enabling vascular reactivity information to be routinely acquired. Journal article Blockley NP. et al, (2017), Neuroimage, 159, 214 - 223 More publications Related Links Imaging Cerebral Physiology Network   Network of scientists interested in imaging brain physiology using MRI FMRIB Physics Group   Focussed on the development of new MRI methodologies FMRI Physiology Group A subsection of the FMRIB Physics Group specialising in techniques to quantify multiple aspects of brain physiology Acute Vascular Imaging Centre (AVIC) Research into new methods of imaging Stroke through the Acute MRI In Cerebral Ischaemia (AMICI)  project © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster


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264 www.rdm.ox.ac.uk/people/rebecca-dean
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266 www.rdm.ox.ac.uk/people/niall-dempster



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