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Title: Mohsin Badat — Radcliffe Department of Medicine
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Texto: Mohsin Badat — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Mohsin Badat Contact information Email mohsin.badat@new.ox.ac.uk Telephone 01865 222367 Research groups Higgs Group: Laboratory of Gene Regulation Mohsin Badat DPhil Student Beta-thalassaemia is a common form of inherited anaemia caused by reduced production of the beta-globin chains that, along with alpha-globin chains, form haemoglobin, the major oxygen carrying molecule in the body. The disrupted balance between the two chains leads to damage to developing red blood cells and is the major pathophysiological driver of the anaemia. Whilst treatments for symptoms are available they are not without their side-effects; beta-thalassaemia still causes thousands of premature deaths each year and so a curative therapy is desperately needed. Gene therapy using the recently developed CRISPR/Cas9 genome-engineering system offers itself as an attractive tool to develop novel therapeutic strategies. My project aims to develop a gene-editing cure for beta-thalassaemia, with two major goals: 1) to identify and edit key regulatory sequences in the alpha-globin locus to restore globin-chain balance and ameliorate the anaemia. 2) to identify which fraction of the haematopoetic stem cell compartment should be edited to generate an efficient and acceptable therapy. We hope that if successful our project can be taken as a model for developing cures for a wide range of genetic diseases. I am a Haematology registrar taking time out from training to undertake basic scientific research. I graduated from the University of Cambridge and trained as a paediatrician in North-East London prior to my current role. Recent publications Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia. Journal article Mettananda S. et al, (2017), Nat Commun, 8 Gene Therapy in a Patient with Sickle Cell Disease. Journal article Badat M. and Davies J., (2017), N Engl J Med, 376, 2093 - 2094 CLL with intra-cytoplasmic lymphocytic inclusion bodies. Journal article Badat M. et al, (2016), Int J Hematol, 104, 411 - 412 Treatment of diffuse large B-cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS-penetrating R-IDARAM chemotherapy. Journal article Maciocia P. et al, (2016), Br J Haematol, 172, 545 - 553 Combination-therapy with concurrent deferoxamine and deferiprone is effective in treating resistant cardiac iron-loading in aceruloplasminaemia. Journal article Badat M. et al, (2015), Br J Haematol, 171, 430 - 432 More publications ORCID 0000-0003-0744-5427 © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Nicolas Bery Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Veronica Alcolea Devesa Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes Vanessa Ferreira Lucy Field Alison Fletcher Gary Ford Nicholas Fordham Helena Francis John Frankland Rachel Franklin Joe Frost Xiaopeng Fu Lars Fugger Lars Fugger Tudor Fulga Kezia Gaitskell Parag Gajendragadkar Silvia Galiani Toby Gamlen Jonathan Gamwell Wei Gan Wei Gan Syed Gardezi Tina Garland


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265 www.rdm.ox.ac.uk/people/edward-drydale
266 www.rdm.ox.ac.uk/people/yue-du
267 www.rdm.ox.ac.uk/people/claire-duff
268 www.rdm.ox.ac.uk/people/samuel-dunkley
269 www.rdm.ox.ac.uk/people/pamela-dyson
270 www.rdm.ox.ac.uk/people/james-early
271 www.rdm.ox.ac.uk/people/james-eaton
272 www.rdm.ox.ac.uk/people/carol-eaton
273 www.rdm.ox.ac.uk/people/laurienne-gardner
274 www.rdm.ox.ac.uk/people/christian-eggeling
275 www.rdm.ox.ac.uk/people/mehroz-ehsan
276 www.rdm.ox.ac.uk/people/jane-ellis
277 www.rdm.ox.ac.uk/people/hanif-esmail
278 www.rdm.ox.ac.uk/people/lise-estcourt
279 www.rdm.ox.ac.uk/people/rachel-etherington
280 www.rdm.ox.ac.uk/people/mark-evans
281 www.rdm.ox.ac.uk/people/tracey-evans
282 www.rdm.ox.ac.uk/people/martyn-ezra
283 www.rdm.ox.ac.uk/people/anne-farmer
284 www.rdm.ox.ac.uk/people/martin-farrall
285 www.rdm.ox.ac.uk/people/martin-fellermeyer
286 www.rdm.ox.ac.uk/people/candida-fenton
287 www.rdm.ox.ac.uk/people/david-ferguson
288 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
289 www.rdm.ox.ac.uk/people/vanessa-ferreira
290 www.rdm.ox.ac.uk/people/lucy-field
291 www.rdm.ox.ac.uk/people/alison-fletcher
292 www.rdm.ox.ac.uk/people/gary-ford
293 www.rdm.ox.ac.uk/people/nicholas-fordham
294 www.rdm.ox.ac.uk/people/helena-francis
295 www.rdm.ox.ac.uk/people/john-frankland
296 www.rdm.ox.ac.uk/people/rachel-franklin
297 www.rdm.ox.ac.uk/people/joe-frost
298 www.rdm.ox.ac.uk/people/xiaopeng-fu
299 www.rdm.ox.ac.uk/people/lars-fugger
300 www.rdm.ox.ac.uk/people/lars-fugger-1
301 www.rdm.ox.ac.uk/people/tudor-fulga
302 www.rdm.ox.ac.uk/people/kezia-gaitskell
303 www.rdm.ox.ac.uk/people/parag-gajendragadkar-1
304 www.rdm.ox.ac.uk/people/silvia-galiani
305 www.rdm.ox.ac.uk/people/toby-gamlen-1
306 www.rdm.ox.ac.uk/people/jonathan-gamwell
307 www.rdm.ox.ac.uk/people/wei-gan
308 www.rdm.ox.ac.uk/people/weigan
309 www.rdm.ox.ac.uk/people/syed-gardezi
310 www.rdm.ox.ac.uk/people/tina-garland



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