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Title: Michael Desborough — Radcliffe Department of Medicine
Description: BMedSci(Hons), MBChB, MRCP, FRCPath, DPhil Michael Desborough - Locum Consultant Haematologist & Honorary Senior Lecturer
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Texto: Michael Desborough — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Michael Desborough Contact information Email michael.desborough@ndcls.ox.ac.uk Research groups Murphy, Roberts and Stanworth Group: Oxford Clinical Research in Transfusion Medicine Colleges Linacre College Michael Desborough BMedSci(Hons), MBChB, MRCP, FRCPath, DPhil Locum Consultant Haematologist & Honorary Senior Lecturer The main focus of my research is assessing whether desmopressin could be used for treatment of thrombocytopenia or platelet dysfunction.   Platelets are a key part of clot formation. Patients with too few platelets, or platelets which are dysfunctional, are vulnerable to bleeding. One way to treat these patients is by transfusing platelets from a blood donor but this approach is often not effective. I am aiming to determine if desmopressin (a drug which increases platelet adhesion by stimulating release of Von Willebrand Factor) could be an effective adjuvant, or alternative treatment.   I am using a combination of methods to assess the value of desmopressin in this setting including meta-analysis of randomised controlled trials; laboratory assessment of thrombus formation under flow; and observational trials. I am leading two randomised placebo-controlled feasibility trials: desmopressin for prevention of bleeding in thrombocytopenia (DRIVE ) and desmopressin for treatment of stroke due to haemorrhage (DASH ). Key publications Desmopressin use for minimising perioperative blood transfusion. Journal article Desborough MJ. et al, (2017), Cochrane Database Syst Rev, 7 Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials. Journal article Desborough MJR. et al, (2017), J Thromb Haemost, 15, 263 - 272 Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials. Journal article Odutayo A. et al, (2017), Lancet Gastroenterol Hepatol, 2, 354 - 360 Effect of restrictive versus liberal red cell transfusion strategies on haemostasis: systematic review and meta-analysis. Journal article Desborough MJR. et al, (2017), Thromb Haemost, 117, 889 - 898 Alternatives to allogeneic platelet transfusion. Journal article Desborough MJR. et al, (2016), Br J Haematol, 175, 381 - 392 Recent publications A single centre retrospective study of low dose prophylaxis with extended half-life factor IX for severe haemophilia B. Journal article Rampotas A. et al, (2020), Haemophilia Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage Journal article Kang Law Z. et al, (2020), Brain Hemorrhages A HaemSTAR is born; a trainee-led, UK-wide research network in haematology. Journal article Nicolson PL. et al, (2019), Clin Med (Lond), 19, 532 - 533 A HaemSTAR-led, UK-wide 'flash-mob' audit of -intravenous immunoglobulin use in immune -thrombocytopenia. Journal article Nicolson P. et al, (2019), Clin Med (Lond), 19, 82 - 83 Rebleeding and Mortality After Lower Gastrointestinal Bleeding in Patients Taking Antiplatelets or Anticoagulants. Journal article Oakland K. et al, (2019), Clin Gastroenterol Hepatol, 17, 1276 - 1284.e3 More publications ORCID 0000-0002-1951-5616 © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft


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