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Title: Melinda Czéh — Radcliffe Department of Medicine
Description: PhD Melinda Czéh - CRUK Clinical Scientist
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Texto: Melinda Czéh — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Melinda Czéh Contact information Email melinda.czeh@ndcls.ox.ac.uk Research groups Nerlov Group: Hematopoietic Stem Cell Genetics Melinda Czéh PhD CRUK Clinical Scientist I am a CRUK Clinical Scientist in the group of Professor Claus Nerlov in the MRC Molecular Haematology Unit at the Weatherall Institute of Molecular Medicine (WIMM). Parallel, I am working as a Paediatric Oncologist in the Department of Paediatric Haematology and Oncology (John Radcliffe Hospital) led by Dr. Kate Wheeler.  I received my PhD from the Free University of Berlin, Germany in 2008. I performed my PhD thesis under the supervision of Professor Thomas Blankenstein by investigating the antitumor immune responses in transgenic mouse models with spontaneous tumor development. Since LoxP-TAg transgenic mice express the oncogenic SV40 TAg only at later age and spontaneously, the model allowed the characterization of antitumor immune responses, especially tolerance mechanisms in a very natural way.   After my PhD I trained in General Paediatrics and Paediatric Haematology and Oncology in the Children´s Hospital of Charité, Berlin and UKM, Münster, Germany from 2007 to 2016. Parallel, I was working as a Clinical/Postdoctoral Fellow by Professor Frank Rosenbauer from 2014 to 2017 in the Institute of Molecular Tumor Biology, Münster. I was investigating the role of epigenetic mechanisms during haematopoietic differentiation. Furthermore, I took part in the characterization of a mouse model with biphenotypic leukaemia and transdifferentiation mechanisms. I moved to Oxford in November 2017 after I had awarded a CRUK Clinical Scientist Fellowship to join the group of Professor Claus Nerlov. My research activity focuses on the role of haematopoietic lineage bias in the development of different types of acute leukaemias and how this contribution changes during ageing. Both AML and ALL are still highly aggressive malignancies that, despite advances in treatment, remain associated with significant mortality and morbidity. Whereas ALL is most commonly observed in paediatric patients, the incidence of AML increases with age, as does the number of recurrent mutations within the malignant clone. Acute leukaemias arise through the sequential acquisition of mutations that lead to pre-leukaemic clonal expansion, followed by leukaemic transformation of lineage-restricted progenitors through their acquisition of ectopic self-renewal and impaired terminal differentiation. HSCs are (with memory lymphocytes as the exception) the only long-lived cells in the haematopoietic system, a property that makes them a key target for the sequential accumulation of leukaemogenic mutations. In my project I would like to investigate the role of haematopoietic stem cells (HSCs) bias in the development of MLL-induced acute leukaemias during ageing. Recent publications Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity. Journal article Czeh M. and Rosenbauer F., (2017), Mol Cell Oncol, 4 Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors. Journal article Riemke P. et al, (2016), EMBO J, 35, 2399 - 2416 Visualizing the dynamic of adoptively transferred T cells during the rejection of large established tumors. Journal article Charo J. et al, (2011), Eur J Immunol, 41, 3187 - 3197 The yin and yang of microglia. Journal article Czeh M. et al, (2011), Dev Neurosci, 33, 199 - 209 The immune response to sporadic colorectal cancer in a novel mouse model. Journal article Czéh M. et al, (2010), Oncogene, 29, 6591 - 6602 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Nicolas Bery Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Veronica Alcolea Devesa Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes Vanessa Ferreira Lucy Field Alison Fletcher Gary Ford Nicholas Fordham Helena Francis John Frankland Rachel Franklin Joe Frost Xiaopeng Fu Lars Fugger Lars Fugger Tudor Fulga Kezia Gaitskell Parag Gajendragadkar Silvia Galiani Toby Gamlen Jonathan Gamwell Wei Gan Wei Gan


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256 www.rdm.ox.ac.uk/people/michael-dodd
257 www.rdm.ox.ac.uk/people/kathleen-dolan
258 www.rdm.ox.ac.uk/people/hamid-dolatshad
259 www.rdm.ox.ac.uk/people/robert-friedrich-donat
260 www.rdm.ox.ac.uk/people/tao-dong
261 www.rdm.ox.ac.uk/people/patricia-douglas
262 www.rdm.ox.ac.uk/people/gillian-douglas
263 www.rdm.ox.ac.uk/people/damien-downes
264 www.rdm.ox.ac.uk/people/alexander-drakesmith
265 www.rdm.ox.ac.uk/people/roy-drissen
266 www.rdm.ox.ac.uk/people/edward-drydale
267 www.rdm.ox.ac.uk/people/yue-du
268 www.rdm.ox.ac.uk/people/claire-duff
269 www.rdm.ox.ac.uk/people/samuel-dunkley
270 www.rdm.ox.ac.uk/people/pamela-dyson
271 www.rdm.ox.ac.uk/people/james-early
272 www.rdm.ox.ac.uk/people/james-eaton
273 www.rdm.ox.ac.uk/people/carol-eaton
274 www.rdm.ox.ac.uk/people/laurienne-gardner
275 www.rdm.ox.ac.uk/people/christian-eggeling
276 www.rdm.ox.ac.uk/people/mehroz-ehsan
277 www.rdm.ox.ac.uk/people/jane-ellis
278 www.rdm.ox.ac.uk/people/hanif-esmail
279 www.rdm.ox.ac.uk/people/lise-estcourt
280 www.rdm.ox.ac.uk/people/rachel-etherington
281 www.rdm.ox.ac.uk/people/mark-evans
282 www.rdm.ox.ac.uk/people/tracey-evans
283 www.rdm.ox.ac.uk/people/martyn-ezra
284 www.rdm.ox.ac.uk/people/anne-farmer
285 www.rdm.ox.ac.uk/people/martin-farrall
286 www.rdm.ox.ac.uk/people/martin-fellermeyer
287 www.rdm.ox.ac.uk/people/candida-fenton
288 www.rdm.ox.ac.uk/people/david-ferguson
289 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
290 www.rdm.ox.ac.uk/people/vanessa-ferreira
291 www.rdm.ox.ac.uk/people/lucy-field
292 www.rdm.ox.ac.uk/people/alison-fletcher
293 www.rdm.ox.ac.uk/people/gary-ford
294 www.rdm.ox.ac.uk/people/nicholas-fordham
295 www.rdm.ox.ac.uk/people/helena-francis
296 www.rdm.ox.ac.uk/people/john-frankland
297 www.rdm.ox.ac.uk/people/rachel-franklin
298 www.rdm.ox.ac.uk/people/joe-frost
299 www.rdm.ox.ac.uk/people/xiaopeng-fu
300 www.rdm.ox.ac.uk/people/lars-fugger
301 www.rdm.ox.ac.uk/people/lars-fugger-1
302 www.rdm.ox.ac.uk/people/tudor-fulga
303 www.rdm.ox.ac.uk/people/kezia-gaitskell
304 www.rdm.ox.ac.uk/people/parag-gajendragadkar-1
305 www.rdm.ox.ac.uk/people/silvia-galiani
306 www.rdm.ox.ac.uk/people/toby-gamlen-1
307 www.rdm.ox.ac.uk/people/jonathan-gamwell
308 www.rdm.ox.ac.uk/people/wei-gan
309 www.rdm.ox.ac.uk/people/weigan



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