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Title: Lars Fugger — Nuffield Department of Clinical Neurosciences
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Texto: Lars Fugger — Nuffield Department of Clinical Neurosciences Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Intranet Accessibility Cookies Contact us Log in Home About us News Research Study With Us People Public Engagement Search People Lars Fugger Contact information Email lars.fugger@imm.ox.ac.uk Telephone 01865 222351 Research groups Oxford Centre for Neuroinflammation Websites Weatherall Institute of Molecular Medicine Lars Fugger Professor of Neuroimmunology Research Summary Multiple sclerosis (MS) is a common chronic inflammatory and degenerative disease of the central nervous system. Inherited susceptibility to MS is primarily associated with certain MHC genes. In addition, unknown environmental factors also seem to play a role in the disease. Our group is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. We are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients. We are taking a multidisciplinary approach which is possible through a strong network of local and international collaborators. There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group. Recent publications Identifying cross-disease components of genetic risk across hospital data in the UK Biobank. Journal article Cortes A. et al, (2019), Nat Genet B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2. Journal article du Pré MF. et al, (2019), The Journal of experimental medicine A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity. Journal article Ooi JD. et al, (2019), Nat Commun, 10 Systematic classification of shared components of genetic risk for common human diseases Working paper Cortes A. et al, (2018) HLA variation and disease Journal article Dendrou CA. et al, (2018), Nature Reviews Immunology, 18, 325 - 339 More publications © 2020 Nuffield Department of Clinical Neurosciences. Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Intranet Accessibility Cookies Contact us Log in About us Working in our Department Staff and Student Clubs Flexible Working Athena SWAN Anti-Bullying and Harassment Sustainability Induction Staff Development Personal Development Reviews Mentoring & Support Networks Staff Development Plan Training you should undertake during your probationary period Joining a College Contact Us News Medical Sciences graduate student named UK's top black student Graduate programmes in neuroscience Litchfield/Thomas Willis Lecture Podcast Available Three of our students in boat race triumph Oxford Biomedical Research Centre Open Day Attracts 600 Department’s Researchers ‘Highly Cited’ Tom Okell wins Royal Academy of Engineering Research Fellowship Smart Glasses Win Google Impact Challenge New research to investigate if neuroscience can improve teaching and learning in schools Russell Foster receives Excellence in Bioscience Communication Award Significant industry funding for pain research Susan Downes wins award for research into inherited retinal disease REF 2014: Oxford Psychology, Psychiatry and Neuroscience excels Russell Foster recognised in New Year Honours New tool being developed to fight motor neuron disease Migraine studentship Celebrating the work of our Department Over 250 people find out about tackling brain diseases New Brain Network Dynamics Unit Stephen Hicks wins award for glasses for blind people Stroke research group wins Queen's Anniversary Prize Martin Turner writes blog on diagnosing MND earlier Bespoke Treatments for Parkinson's Neurosurgeon awarded Hunterian Professorship New treatments for migraine pain control Oxford Headache Centre Launched Tipu Aziz awarded lectureship at Baylor College of Medicine Two major grants for Oxford's Parkinson's research Smart glasses for people with poor vision being tested in Oxford Motor Neuron Researchers do the Ice Bucket Challenge MRI brain scans detect people with early Parkinson’s Stephen Hicks Wins Prize for Smart Glasses Epilepsy Research UK’s 20th Year – Award for NDCN Researchers Stem cells for Biological Assays of Novel drugs and predictive toxiCology (StemBANCC) OCHNCTU – the new name in clinical trials units New Member of Staff Profile – Dr David Bennett London International Youth Science Forum Visits Oxford Neuroscience Athena Swan Award Ceremony NDCN Awarded Athena Swan Bronze Award New Genetic Disorder Discovered by NDCN Team Recent Oxford Neuroscience Successes New Action Research Professor of Clinical Neurology Announced Prof Ebers awarded American Academy of Neurology Prize for MS research New scanner for functional MRI research Irene Tracey awarded Fellowship of the Academy of Medical Sciences Learn about functional and structural brain image analysis on the 2015 FSL course Researchers pinpoint degrees of consciousness during anaesthesia Linking development, ageing, and disease processes in the brain Sleep deprivation may shrink the brain Oxford Centre for Functional MRI of the Brain opens its doors Study shows how human brain learns to handle disability UK Biobank Imaging Extension Approved New FMRI Technique Produces Quantitative Measurement of Cerebral Physiology Studentship in MRI Physics Amputee pain linked to retained picture of missing limb Computer algorithm picks out the drugs that work 'Ouch zone' in the brain identified Babies and adults show similar patterns of pain-related brain activity Ruby wax tour of the brain 2014 FSL course announced Researchers aim to help patients sleep better during their stay in hospital Landmark in stroke treatement First UK study of ketamine for people with severe depression Researchers pinpoint degrees of consciousness during anaesthesia The Oxford Sleep and Circadian Neuroscience Summer Schools 'Arrogance' of ignoring need for sleep Great British Sleep Survey Launched Researcher’s company wins innovation award Exhibition at Oxford’s Museum of Natural History showcases research TEDTalk by Oxford Professor Promising first results in gene therapy trial for inherited blindness Professor MacLaren awarded prize Colin Espie on the impact of poor sleep on health How much can an extra hour's sleep change you? Russell Foster on sleep science at the 2014 Wired Health Event Cheltenham Science Festival First UK Retinal Implant Successfully Restores Vision Professor Foster Wins BBSRC Social Innovator of the Yea Russell Foster elected Fellow of the Academy of Medical Sciences Two Wellcome Trust Strategic Awards Confirmed Professorship for NLO student New stem cell approach for blindness successful in mice Royal Society of Medicine prize for gene therapy researcher Sleep researchers contribute to lighting innovation Aviation study shows lower air pressure leads to higher blood pressure in lungs The Oxford Online Programme in Sleep Medicine Research shows possible way to prevent degenerative eye condition London school students meet our scientists Aarti Jagannath wins 2015 For Women In Science Award Sleep deprivation could reduce intrusive memories of traumatic scenes Russell Foster receives Nikken International Science Award Pioneering eye research to feature on One Show Gene therapy gives long-term protection to photoreceptor cells in a mouse model of retinitis pigmentosa Research group demonstrate brain stimulation using watermelons Nuffield Laboratory of Ophthalmology Student becomes Professor Martin Turner becomes a Professor The effects of working the night shift International students visit our department to learn about neuroscience New system to identify patients at risk of admission to intensive care Christopher Kennard wins 2015 Koetser Award Pedalling like a professional is a losing strategy for most cyclists Anaesthetist Jaideep Pandit wins British Medical Association Award Our researchers test health technology on zero gravity flights with NASA Registration now open for MRI-based neuroimaging in research courses Particular brain connections linked to positive human traits Athena SWAN Silver Award New £1.3m research consortium for spinal muscular atrophy £50,000 dementia drug discovery project gets underway New evidence on how deep brain stimulation works New insight into light detection in vertebrates New Fellow to develop treatment for retinal disorder Martin Turner receives Graham Bull Prize Patients, carers, and researchers discuss a rare form of motor neuron disease What makes you tick? £23 million boost for Oxford spinout company Why sleep could be the key to tackling mental illness Brain structure may be root of apathy Angela Vincent receives British Neuroscience Association Award Teaching old drugs new tricks Celebrating 50 years of the British Neuroscience Association Blind woman’s joy as she is able to read the time thanks to 'bionic eye' Wellcome Trust Award for work on plasticity O


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