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Title: Ioannis Akoumianakis — Radcliffe Department of Medicine
Description: MD, DPhil (Oxon) Ioannis Akoumianakis - Research Associate, Division of Cardiovascular Medicine
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Texto: Ioannis Akoumianakis — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Ioannis Akoumianakis Contact information Email ioannis.akoumianakis@cardiov.ox.ac.uk Research groups Antoniades Group: The Oxford Translational Cardiovascular Research Group Ioannis Akoumianakis MD, DPhil (Oxon) Research Associate, Division of Cardiovascular Medicine My research focuses on investigating the direct vascular effects of insulin in humans with atherosclerosis, and how these may be influenced by molecules that the adipose tissue (AT) secretes. Obesity, insulin resistance and diabetes comprise interrelated entities linked to increased risk for vascular complications. Despite recent advances, there is still an unmet need to explore the biology underlying the vascular effects of these global metabolic disease burdens. Work from our group has identified AT as a dynamic regulator of vascular function via the secretion of molecules called adipokines. Importantly, the secretome of AT may undergo drastic changes in response to obesity and diabetes, with direct, and not adequately characterised, implications for vascular disease. During my collaboration with the Antoniades Group, I have been focusing on performing various ex vivo techniques using fresh human tissue to investigate the effects of obesity and diabetes on the human vasculature in multiple levels, while driving the management of the actively recruiting Oxford cohort for Heart, Vessels and Fat (Ox-HVF). Ox-HVF comprises a unique bioresource able to provide invaluable insights into the molecular mechanisms governing vascular injury associated with obesity and diabetes, as well as the role of AT in regulating such mechanisms. Key publications Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Journal article Akoumianakis I. et al, (2019), Sci Transl Med, 11 Insulin Treatment Induces Oxidative Stress in the Vascular Wall of Patients With Atherosclerosis Independently of Diabetes or Systemic Insulin Resistance: The Protective Role of DPP-IV Inhibition Conference paper Akoumianakis I. et al, (2017), CIRCULATION, 136 A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Journal article Oikonomou EK. et al, (2019), Eur Heart J, 40, 3529 - 3543 Detecting human coronary inflammation by imaging perivascular fat. Journal article Antonopoulos AS. et al, (2017), Sci Transl Med, 9 Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus. Journal article Akoumianakis I. and Antoniades C., (2019), Antioxid Redox Signal, 30, 333 - 353 The interplay between adipose tissue and the cardiovascular system: is fat always bad? Journal article Akoumianakis I. and Antoniades C., (2017), Cardiovasc Res, 113, 999 - 1008 Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets. Journal article Akoumianakis I. et al, (2017), Br J Pharmacol, 174, 3411 - 3424 Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease. Journal article Akoumianakis I. and Antoniades C., (2017), Vascul Pharmacol, 96-98, 1 - 4 Recent publications Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction. Journal article Meakin PJ. et al, (2020), J Clin Invest Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition. Journal article Akoumianakis I. et al, (2020), Sci Transl Med, 12 Highlights of AHA Scientific Sessions 2019: novel approaches in cardiovascular risk reduction. Journal article Akoumianakis I., (2020), Cardiovasc Res, 116, e16 - e18 A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Journal article Oikonomou EK. et al, (2019), Eur Heart J, 40, 3529 - 3543 A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Journal article Douglas G. et al, (2019), Cardiovasc Res More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump


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