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Title: Houman Ashrafian — Radcliffe Department of Medicine
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Texto: Houman Ashrafian — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Houman Ashrafian Contact information Email houman.ashrafian@cardiov.ox.ac.uk Research groups Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Watkins Group: Inherited Heart Muscle Disease Group Houman Ashrafian Visiting Professor of Experimental Therapeutics Cell and Molecular Biology Cardiac metabolism and function are inextricably linked. Maintaining energy flux is essential to the functioning of the heart which requires more energy (ATP) per gram of tissue than any other organ. The heart consumes approximately ~8–15 ml O2/min/100 g tissue compared to the brain’s ~3 ml O2/min/100 g tissue. Matching the supply of metabolic substrates to myocardial work, requiring more than 70 ml O2/min/100 g tissue during vigorous exercise, requires profound adaptive cellular responses for generating ATP over large dynamic and temporal ranges. It is therefore unsurprising that metabolism has been linked to cardiac health and disease. As altered metabolism is thought to be central to the energy deficiency of heart failure and cardiomyopathy, it is likely that variations in metabolism contribute to the clinical heterogeneity of cardiomyopathy. Characterising cardiac metabolism in different models of cardiomyopathy is therefore likely to: (i) contribute to our understanding of fundamental cardiac pathophysiology, (ii) illuminate the basis of its clinical variability and delineate disease subgroups by identifying stratifying diagnostic biomarkers and (iii) guide novel metabolic therapeutic strategies. By striving to understand basic mechanisms determining the complexity of cardiac metabolism, for example by investigating pathways identified in cancer medicine to the cardiovascular system, we aim to take translate these insights from bench to bedside. Our work demonstrating the cardioprotective properties of basic biological molecules such as fumarate and insulin underline the potential for discovery biology to have a rapid clinical impact. Our identification and exemplification of perhexiline (a metabolic modulator), in conjunction with collaborators in Aberdeen and London, as a promising treatment for defined subgroups of patients with cardiomyopathy and heart failure, supports the value of this metabolic strategy for diagnostic and therapeutic progress. Recent publications MiR-184 expression is regulated by AMPK in pancreatic islets. Journal article Martinez-Sanchez A. et al, (2018), FASEB J, 32, 2587 - 2600 Mammalian γ2 AMPK regulates intrinsic heart rate. Journal article Yavari A. et al, (2017), Nat Commun, 8 Aggressive restenosis after percutaneous intervention in two coronary loci in a patient with human immunodeficiency virus infection. Journal article Alkhalil M. et al, (2017), World J Clin Cases, 5, 40 - 45 Human Second Window Pre-Conditioning and Post-Conditioning by Nitrite Is Influenced by a Common Polymorphism in Mitochondrial Aldehyde Dehydrogenase. Journal article Ormerod JOM. et al, (2017), JACC Basic Transl Sci, 2, 13 - 21 Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. Journal article Cahill TJ. et al, (2016), J Biol Chem, 291 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Accessibility statement Accessibility: known issues Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Charalambos Antoniades Alex Antonopoulos Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Charlotte Brierley Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Ronjon Chakraverty Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Greig Dougall Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Oliver Featherstone Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes Vanessa Ferreira


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261 www.rdm.ox.ac.uk/people/tomasz-dobrzycki
262 www.rdm.ox.ac.uk/people/cameron-dockerill
263 www.rdm.ox.ac.uk/people/michael-dodd
264 www.rdm.ox.ac.uk/people/kathleen-dolan
265 www.rdm.ox.ac.uk/people/hamid-dolatshad
266 www.rdm.ox.ac.uk/people/robert-friedrich-donat
267 www.rdm.ox.ac.uk/people/tao-dong
268 www.rdm.ox.ac.uk/people/greig-dougall
269 www.rdm.ox.ac.uk/people/patricia-douglas
270 www.rdm.ox.ac.uk/people/gillian-douglas
271 www.rdm.ox.ac.uk/people/damien-downes
272 www.rdm.ox.ac.uk/people/alexander-drakesmith
273 www.rdm.ox.ac.uk/people/roy-drissen
274 www.rdm.ox.ac.uk/people/edward-drydale
275 www.rdm.ox.ac.uk/people/yue-du
276 www.rdm.ox.ac.uk/people/claire-duff
277 www.rdm.ox.ac.uk/people/samuel-dunkley
278 www.rdm.ox.ac.uk/people/pamela-dyson
279 www.rdm.ox.ac.uk/people/james-early
280 www.rdm.ox.ac.uk/people/james-eaton
281 www.rdm.ox.ac.uk/people/carol-eaton
282 www.rdm.ox.ac.uk/people/laurienne-gardner
283 www.rdm.ox.ac.uk/people/christian-eggeling
284 www.rdm.ox.ac.uk/people/mehroz-ehsan
285 www.rdm.ox.ac.uk/people/jane-ellis
286 www.rdm.ox.ac.uk/people/hanif-esmail
287 www.rdm.ox.ac.uk/people/lise-estcourt
288 www.rdm.ox.ac.uk/people/rachel-etherington
289 www.rdm.ox.ac.uk/people/mark-evans
290 www.rdm.ox.ac.uk/people/tracey-evans
291 www.rdm.ox.ac.uk/people/martyn-ezra
292 www.rdm.ox.ac.uk/people/anne-farmer
293 www.rdm.ox.ac.uk/people/martin-farrall
294 www.rdm.ox.ac.uk/people/oliver-featherstone
295 www.rdm.ox.ac.uk/people/martin-fellermeyer
296 www.rdm.ox.ac.uk/people/candida-fenton
297 www.rdm.ox.ac.uk/people/david-ferguson
298 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
299 www.rdm.ox.ac.uk/people/vanessa-ferreira



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