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Title: Graham Davies — Radcliffe Department of Medicine
Description: Graham Davies - Head of Chemokine Technology Development
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Texto: Graham Davies — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Graham Davies Contact information Email daviesgn@well.ox.ac.uk Research groups Bhattacharya Group: Developing novel therapeutics for inflammatory diseases Graham Davies Head of Chemokine Technology Development My research is focussed on discovering and developing new drugs that can be used to treat heart diseases where inflammation plays a major role. Through employing yeast surface display a number of small proteins called evasins have been identified from tick saliva. These evasins have a unique “one-to-many” mechanism of action, i.e. they bind multiple chemokines, and potently block inflammation. The “one-to-many” action of the evasins overcomes the robustness of the chemokine system, which is unaffected by traditional anti-chemokine drugs that work on a “one-to-one” basis. Chemokines are produced by the body in response to injury, and bring in white blood cells that cause further damage through a process known as migration. I have developed a number of techniques utilising high throughput flow cytometry to functionally validate the evasins. These include fluorescent ligand binding/competition assays and a raft of human and mouse primary cell migration assays. My current work is focussed on the development of the delivery of the evasins to site of inflammation and the development of a bacterial cell surface display technique to enable identification of critical residues in the evasin:chemokine interaction. Recent publications Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Journal article Alenazi Y. et al, (2018), Sci Rep, 8 The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins. Journal article Eaton JRO. et al, (2018), J Biol Chem, 293, 6134 - 6146 Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities. Journal article Singh K. et al, (2017), Sci Rep, 7 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Nicolas Bery Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Veronica Alcolea Devesa Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes Vanessa Ferreira Lucy Field Alison Fletcher Gary Ford Nicholas Fordham Helena Francis John Frankland Rachel Franklin Joe Frost Xiaopeng Fu Lars Fugger Lars Fugger Tudor Fulga Kezia Gaitskell Parag Gajendragadkar Silvia Galiani Toby Gamlen Jonathan Gamwell Wei Gan Wei Gan Syed Gardezi Tina Garland Katja Gehmlich Cristina Di Genua Charlotte George Emily Georgiades Sahar Ghaffari Richard Gibbons Maria Giebler Deborah Gill Anne Gilligan Anna Gloyn Anna Gluck Anuj Goel Tomas Goncalves Claudia Gonzalez-Lopez Sarah Gooding Anne Goriely Matthew Gosden Stephen Gough Stephen Gough Michelle Gould


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270 www.rdm.ox.ac.uk/people/carol-eaton
271 www.rdm.ox.ac.uk/people/laurienne-gardner
272 www.rdm.ox.ac.uk/people/christian-eggeling
273 www.rdm.ox.ac.uk/people/mehroz-ehsan
274 www.rdm.ox.ac.uk/people/jane-ellis
275 www.rdm.ox.ac.uk/people/hanif-esmail
276 www.rdm.ox.ac.uk/people/lise-estcourt
277 www.rdm.ox.ac.uk/people/rachel-etherington
278 www.rdm.ox.ac.uk/people/mark-evans
279 www.rdm.ox.ac.uk/people/tracey-evans
280 www.rdm.ox.ac.uk/people/martyn-ezra
281 www.rdm.ox.ac.uk/people/anne-farmer
282 www.rdm.ox.ac.uk/people/martin-farrall
283 www.rdm.ox.ac.uk/people/martin-fellermeyer
284 www.rdm.ox.ac.uk/people/candida-fenton
285 www.rdm.ox.ac.uk/people/david-ferguson
286 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
287 www.rdm.ox.ac.uk/people/vanessa-ferreira
288 www.rdm.ox.ac.uk/people/lucy-field
289 www.rdm.ox.ac.uk/people/alison-fletcher
290 www.rdm.ox.ac.uk/people/gary-ford
291 www.rdm.ox.ac.uk/people/nicholas-fordham
292 www.rdm.ox.ac.uk/people/helena-francis
293 www.rdm.ox.ac.uk/people/john-frankland
294 www.rdm.ox.ac.uk/people/rachel-franklin
295 www.rdm.ox.ac.uk/people/joe-frost
296 www.rdm.ox.ac.uk/people/xiaopeng-fu
297 www.rdm.ox.ac.uk/people/lars-fugger
298 www.rdm.ox.ac.uk/people/lars-fugger-1
299 www.rdm.ox.ac.uk/people/tudor-fulga
300 www.rdm.ox.ac.uk/people/kezia-gaitskell
301 www.rdm.ox.ac.uk/people/parag-gajendragadkar-1
302 www.rdm.ox.ac.uk/people/silvia-galiani
303 www.rdm.ox.ac.uk/people/toby-gamlen-1
304 www.rdm.ox.ac.uk/people/jonathan-gamwell
305 www.rdm.ox.ac.uk/people/wei-gan
306 www.rdm.ox.ac.uk/people/weigan
307 www.rdm.ox.ac.uk/people/syed-gardezi
308 www.rdm.ox.ac.uk/people/tina-garland
309 www.rdm.ox.ac.uk/people/katja-gehmlich
310 www.rdm.ox.ac.uk/people/cristina-di-genua
311 www.rdm.ox.ac.uk/people/charlotte-george
312 www.rdm.ox.ac.uk/people/emily-georgiades
313 www.rdm.ox.ac.uk/people/sahar-ghaffari
314 www.rdm.ox.ac.uk/people/richard-gibbons
315 www.rdm.ox.ac.uk/people/maria-giebler
316 www.rdm.ox.ac.uk/people/deborah-gill
317 www.rdm.ox.ac.uk/people/anne-gilligan
318 www.rdm.ox.ac.uk/people/anna-gloyn
319 www.rdm.ox.ac.uk/people/anna-gluck
320 www.rdm.ox.ac.uk/people/anuj-goel
321 www.rdm.ox.ac.uk/people/tomas-goncalves
322 www.rdm.ox.ac.uk/people/claudia-gonzalez-lopez
323 www.rdm.ox.ac.uk/people/sarah-gooding
324 www.rdm.ox.ac.uk/people/anne-goriely
325 www.rdm.ox.ac.uk/people/matthew-gosden
326 www.rdm.ox.ac.uk/people/stephen-gough
327 www.rdm.ox.ac.uk/people/stephen-gough-1
328 www.rdm.ox.ac.uk/people/michelle-gould



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