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Title: Deborah Gill — Radcliffe Department of Medicine
Description: PhD, BSc (Hons) Deborah Gill - Professor of Gene Medicine
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Texto: Deborah Gill — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Deborah Gill Contact information Email deborah.gill@ndcls.ox.ac.uk PA Tina Garland tina.garland@ndcls.ox.ac.uk Research groups Gill and Hyde Group: Gene Medicine Group Websites The UK Cystic Fibrosis Gene Therapy Consortium The UK Cystic Fibrosis Gene Therapy Consortium DPhil Supervisor Profile Gill Group – Development of Gene Therapy and Gene Editing for Lung Disorders Deborah Gill PhD, BSc (Hons) Professor of Gene Medicine Gene Therapy for Lung diseases Deborah Gill is based in the John Radcliffe Hospital in Oxford where she is Professor of Gene Medicine and Co-Director of the Gene Medicine Research Group. Deborah completed her PhD in molecular microbiology at the University of Warwick, studying cell division proteins in E.coli, during which she discovered the  defining bacterial member of the ABC (ATP-Binding Cassette) superfamily of proteins. In 1990, Deborah moved to the University of Oxford, to undertake post-doctoral research under the mentorship of Professor Chris Higgins at the Weatherall Institute for Molecular Medicine, investigating human ABC proteins including the Multi-Drug Resistance p-glycoprotein and CFTR, the protein responsible for Cystic Fibrosis (CF). Together with Dr Steve Hyde, Deborah's research began to evaluate gene therapy for genetic diseases, focusing on a potential treatment for Cystic Fibrosis lung disease. Two clinical trials in CF  patients were undertaken in collaboration with Sir Martin Evans, and Professors Bill Colledge and Alan Cuthbert at Cambridge University, demonstrating proof of principle for non-viral (plasmid-based) CF gene therapy in the upper airways. In 2001, Deborah was a founding member of the UK CF Gene Therapy Consortium, joining together the Gene Medicine Research Group, University of Oxford; the Centre for Molecular Medicine and Roslin Institute, University of Edinburgh; and, the Department of Gene Therapy, National Heart & Lung Institute, Imperial College London. This consortium of scientists and clinicians continues to work towards making gene therapy a reality for patients with CF. The Consortium completed the world's largest gene therapy trial - a phase llb study involving 136 participants - delivering an aerosol of non-viral gene therapy at monthly intervals for 12 months. The study showed a clinically relevant improvement in lung function in those receiving gene therapy, compared with those receiving a placebo treatment. However, more efficient gene delivery strategies are needed. The success of gene therapy to introduce genes into cells and gene editing to correct genetic mutations, ultimately depends on efficient delivery of genetic material to human cells. Much of Deborah's current research is focused on development of Lentiviral and AAV vectors for translation of new gene therapies to the clinic. In addition to targeting genetic lung diseases Deborah's research group is evaluating whether the airways can be used as a 'protein factory' to make therapeutic proteins and antibodies. As well as undertaking translational research, Deborah is involved in many aspects of graduate student mentoring and training. She has supervised many DPhil and Masters students to completion of their post-graduate degrees and is currently the Chair of Oxford University's Graduate School Committee for the Medical Sciences Division. Key publications Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial. Journal article Alton EWFW. et al, (2015), Lancet Respir Med, 3, 684 - 691 CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression. Journal article Hyde SC. et al, (2008), Nat Biotechnol, 26, 549 - 551 Recent publications Human embryonic stem cell derived lung organoids for screening of AAV gene therapy vectors Working paper Meyer-Berg H. et al, (2020) Lung targeting lentiviral vector for passive immunisation against influenza Working paper TAN T. et al, (2020) Emerging gene therapies for cystic fibrosis. Journal article Miah KM. et al, (2019), Expert Rev Respir Med, 1 - 17 Gene therapy for surfactant protein B deficiency using recombinant AAV Conference paper Meyer-Berg H. et al, (2019) Genome Editing of the Liver for Treatment of Alpha-1 Antitrypsin Deficiency Using Homology-Independent Targeted Integration (HITI) Conference paper van Haasteren J. et al, (2019) More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki


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251 www.rdm.ox.ac.uk/people/rinita-dam
252 www.rdm.ox.ac.uk/people/matthew-daniels
253 www.rdm.ox.ac.uk/people/lorna-daniels
254 www.rdm.ox.ac.uk/people/carol-davey
255 www.rdm.ox.ac.uk/people/james-davies
256 www.rdm.ox.ac.uk/people/graham-davies
257 www.rdm.ox.ac.uk/people/simon-davis
258 www.rdm.ox.ac.uk/people/james-dean
259 www.rdm.ox.ac.uk/people/rebecca-dean
260 www.rdm.ox.ac.uk/people/atanasiu-stefan-demian
261 www.rdm.ox.ac.uk/people/niall-dempster
262 www.rdm.ox.ac.uk/people/louise-dennis
263 www.rdm.ox.ac.uk/people/timothy-dent
264 www.rdm.ox.ac.uk/people/geoffrey-denwood
265 www.rdm.ox.ac.uk/people/michael-desborough
266 www.rdm.ox.ac.uk/people/matthew-dickinson
267 www.rdm.ox.ac.uk/people/marina-diotallevi
268 www.rdm.ox.ac.uk/people/tomasz-dobrzycki



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