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Title: Daniel Beard — Radcliffe Department of Medicine
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Texto: Daniel Beard — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Daniel Beard Contact information Email daniel.beard@rdm.ox.ac.uk Telephone +44 (0)186522049 Research groups Buchan Group: Laboratory of Cerebral Ischemia Colleges Corpus Christi College Harris Manchester College BIOGRAPHY Dr Beard completed his PhD (Human Physiology) in 2015 in the Translational Stroke Laboratory of Professor Neil Spratt at the University of Newcastle, Australia. His PhD thesis investigated the mechanisms regulating collateral blood flow after stroke. He found that changes in intracranial pressure (ICP) profoundly reduced collateral blood flow to the ischaemic brain during stroke. This work generated the novel hypothesis, that changes in ICP in human stroke may be the cause of the previously identified, but poorly understood phenomenon of collateral vessel failure and neurological deterioration in a subset of stroke patients. This work provided the stimulus for clinical investigations to the test this novel hypothesis. In September 2016, Dr Beard took up a postdoctoral position in the Laboratory of Cerebral Ischaemia of Professor Alastair Buchan at the University of Oxford. In this role he is continuing to research the important role of the cerebral vasculature in determining stroke outcome. Specifically, he is now focusing on cytoprotective therapies that can protect the cells that make up the capillaries of the brain as a means of improving microvascular perfusion, reducing blood brain barrier disruption and ultimately improving neurological outcome after stroke. As well as his research pursuits, Dr Beard has continued to develop his expertise as a university educator. He is currently a tutor in physiology at Corpus Christi College and Harris Manchester College.   Daniel Beard Postdoctoral Scientist Research Interests   I am interested in both cardiovascular physiology and neuroscience, in particular how the cardiovascular system affects the functioning of the nervous system. This lead me to my current field of research in ischaemic stroke, a disease in which disruption of blood flow to the brain (by a clot) has a profound and often devastating affect on brain function leading to death and disability. I am particularly interested in how the function of the blood vessels in the brain influences brain function and ultimately neurological outcome after stroke.  During my doctoral studies I investigated a set of so called “bypass” or collateral vessels in the brain. These vessels allow blood to flow around the clot towards the compromised but still saveable tissue of the brain called the penumbra. The degree of flow through these vessels is a very important predictor of stroke outcome. I identified that an increase in pressure within the skull after stroke severely reduces flow through these vessels (termed collateral failure), which may lead to neurological deterioration in stroke patients in which the clot is unable to be removed.  Fortunately for stroke patients there are treatments available to dissolve (with a drug known as tPA) or remove (with intra-arterial clot retrieval devices) the clot. Unfortunately for some stroke patients, reopening the occluded vessel affords no-improvement, as adequate restoration of blood flow to the capillaries of the brain is not achieved, termed “no-reflow phenomenon”. Very recent evidence suggests that constriction and subsequent death of pericytes that surround the capillaries is responsible for this lack of blood flow to the capillaries. Furthermore, death of pericytes, endothelial cells and astrocytes compromises the blood brain barrier, which can further complicate reperfusion therapies due to increased risk of vessel rupture and bleeding.  My current research at the University of Oxford is investigating novel therapies with cytoprotective effects in multiple cells types within the cerebral capillaries. I am particular interested in therapies that can reduce the constriction and subsequent death of pericytes as a means of improving capillary blood flow and reducing blood brain barrier disruption following stroke.  Recent publications Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia. Journal article Hadley G. et al, (2019), Neurosci Lett, 706, 223 - 230 The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies Journal article Beard DJ. et al, (2019), International Journal of Stroke, 14, 137 - 145 Rapamycin in ischemic stroke: Old drug, new tricks? Journal article Hadley G. et al, (2019), J Cereb Blood Flow Metab, 39, 20 - 35 The role of the endoplasmic reticulum stress response following cerebral ischemia. Journal article Hadley G. et al, (2018), Int J Stroke, 13, 379 - 390 Intracranial pressure elevation is delayed following intracerebral hemorrhage in rats Conference paper Warren KE. et al, (2017), JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37, 186 - 187 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Patricia Douglas Gillian Douglas Damien Downes


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253 www.rdm.ox.ac.uk/people/james-dean
254 www.rdm.ox.ac.uk/people/rebecca-dean
255 www.rdm.ox.ac.uk/people/atanasiu-stefan-demian
256 www.rdm.ox.ac.uk/people/niall-dempster
257 www.rdm.ox.ac.uk/people/louise-dennis
258 www.rdm.ox.ac.uk/people/timothy-dent
259 www.rdm.ox.ac.uk/people/geoffrey-denwood
260 www.rdm.ox.ac.uk/people/michael-desborough
261 www.rdm.ox.ac.uk/people/matthew-dickinson
262 www.rdm.ox.ac.uk/people/marina-diotallevi
263 www.rdm.ox.ac.uk/people/tomasz-dobrzycki
264 www.rdm.ox.ac.uk/people/cameron-dockerill
265 www.rdm.ox.ac.uk/people/michael-dodd
266 www.rdm.ox.ac.uk/people/kathleen-dolan
267 www.rdm.ox.ac.uk/people/hamid-dolatshad
268 www.rdm.ox.ac.uk/people/robert-friedrich-donat
269 www.rdm.ox.ac.uk/people/tao-dong
270 www.rdm.ox.ac.uk/people/patricia-douglas
271 www.rdm.ox.ac.uk/people/gillian-douglas
272 www.rdm.ox.ac.uk/people/damien-downes



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