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Title: Constantinos Christodoulides — Radcliffe Department of Medicine
Description: MBChB, MRCP, PhD Constantinos Christodoulides - University Research Lecturer
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Texto: Constantinos Christodoulides — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Constantinos Christodoulides Contact information Email costas.christodoulides@ocdem.ox.ac.uk Telephone +44 (0)1865 857111 Research groups Karpe, Hodson and Christodoulides Group: Metabolic Research Group Websites British Heart Foundation Funder Constantinos Christodoulides MBChB, MRCP, PhD University Research Lecturer British Heart Foundation Intermediate Clinical Research Fellow Cell and Molecular Biology My work focuses on understanding how obesity leads to the development of diabetes and cardiovascular disease. In particular, my research aims to understand how a family of growth factors, known as Wnts regulates adipocyte number (adipose tissue 'expandability') and distribution within the body; two key determinants of susceptibility to obesity-associated cardiometabolic disease. In order to achieve this we employ human genetic and physiological approaches, accompanied by functional studies in human fat depot-specific cellular models. Recently we identified a key Wnt receptor, LRP5, as a novel human fat distribution gene. Of interest LRP5 is a current drug target for the treatment of osteoporosis illustrating the translational potential of the research. In the longer term we hope to exploit our findings to develop novel therapies for obesity and cardiometabolic diseases. I am currently a BHF Intermediate Clinical Research Fellow and Honorary Consultant in Endocrinology and Diabetes. Prior to this I competed my PhD at the University of Cambridge before taking up an Academic Clinical Lecturer post at the University of Oxford. Recent publications Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states. Journal article Liu J. et al, (2019), Biochim Biophys Acta Mol Cell Biol Lipids, 1864 The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study. Journal article Vasan SK. et al, (2019), Diabetologia, 62, 2079 - 2087 Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Journal article Akoumianakis I. et al, (2019), Sci Transl Med, 11 Associations of Outdoor Temperature, Bright Sunlight, and Cardiometabolic Traits in Two European Population-Based Cohorts. Journal article Noordam R. et al, (2019), J Clin Endocrinol Metab, 104, 2903 - 2910 The diabetes risk gene TCF7L2 regulates human adipose progenitor cell biology Conference paper Verma M. et al, (2018), DIABETOLOGIA, 61, S12 - S12 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Nicolas Bery Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Vincenzo Cerundolo Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Veronica Alcolea Devesa Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes Vanessa Ferreira Lucy Field Alison Fletcher Gary Ford Nicholas Fordham Helena Francis John Frankland Rachel Franklin Joe Frost Xiaopeng Fu Lars Fugger Lars Fugger Tudor Fulga Kezia Gaitskell


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267 www.rdm.ox.ac.uk/people/yue-du
268 www.rdm.ox.ac.uk/people/claire-duff
269 www.rdm.ox.ac.uk/people/samuel-dunkley
270 www.rdm.ox.ac.uk/people/pamela-dyson
271 www.rdm.ox.ac.uk/people/james-early
272 www.rdm.ox.ac.uk/people/james-eaton
273 www.rdm.ox.ac.uk/people/carol-eaton
274 www.rdm.ox.ac.uk/people/laurienne-gardner
275 www.rdm.ox.ac.uk/people/christian-eggeling
276 www.rdm.ox.ac.uk/people/mehroz-ehsan
277 www.rdm.ox.ac.uk/people/jane-ellis
278 www.rdm.ox.ac.uk/people/hanif-esmail
279 www.rdm.ox.ac.uk/people/lise-estcourt
280 www.rdm.ox.ac.uk/people/rachel-etherington
281 www.rdm.ox.ac.uk/people/mark-evans
282 www.rdm.ox.ac.uk/people/tracey-evans
283 www.rdm.ox.ac.uk/people/martyn-ezra
284 www.rdm.ox.ac.uk/people/anne-farmer
285 www.rdm.ox.ac.uk/people/martin-farrall
286 www.rdm.ox.ac.uk/people/martin-fellermeyer
287 www.rdm.ox.ac.uk/people/candida-fenton
288 www.rdm.ox.ac.uk/people/david-ferguson
289 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes
290 www.rdm.ox.ac.uk/people/vanessa-ferreira
291 www.rdm.ox.ac.uk/people/lucy-field
292 www.rdm.ox.ac.uk/people/alison-fletcher
293 www.rdm.ox.ac.uk/people/gary-ford
294 www.rdm.ox.ac.uk/people/nicholas-fordham
295 www.rdm.ox.ac.uk/people/helena-francis
296 www.rdm.ox.ac.uk/people/john-frankland
297 www.rdm.ox.ac.uk/people/rachel-franklin
298 www.rdm.ox.ac.uk/people/joe-frost
299 www.rdm.ox.ac.uk/people/xiaopeng-fu
300 www.rdm.ox.ac.uk/people/lars-fugger
301 www.rdm.ox.ac.uk/people/lars-fugger-1
302 www.rdm.ox.ac.uk/people/tudor-fulga
303 www.rdm.ox.ac.uk/people/kezia-gaitskell



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