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Title: Constantinos Christodoulides — Radcliffe Department of Medicine
Description: MBChB, MRCP, PhD Constantinos Christodoulides - University Research Lecturer
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Texto: Constantinos Christodoulides — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Constantinos Christodoulides Contact information Email costas.christodoulides@ocdem.ox.ac.uk Telephone +44 (0)1865 857111 Research groups Karpe, Hodson and Christodoulides Group: Metabolic Research Group Websites British Heart Foundation Funder Constantinos Christodoulides MBChB, MRCP, PhD University Research Lecturer British Heart Foundation Intermediate Clinical Research Fellow Cell and Molecular Biology My work focuses on understanding how obesity leads to the development of diabetes and cardiovascular disease. In particular, my research aims to understand how a family of growth factors, known as Wnts regulates adipocyte number (adipose tissue 'expandability') and distribution within the body; two key determinants of susceptibility to obesity-associated cardiometabolic disease. In order to achieve this we employ human genetic and physiological approaches, accompanied by functional studies in human fat depot-specific cellular models. Recently we identified a key Wnt receptor, LRP5, as a novel human fat distribution gene. Of interest LRP5 is a current drug target for the treatment of osteoporosis illustrating the translational potential of the research. In the longer term we hope to exploit our findings to develop novel therapies for obesity and cardiometabolic diseases. I am currently a BHF Intermediate Clinical Research Fellow and Honorary Consultant in Endocrinology and Diabetes. Prior to this I competed my PhD at the University of Cambridge before taking up an Academic Clinical Lecturer post at the University of Oxford. Recent publications RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. Journal article Loh NY. et al, (2020), Nat Commun, 11 LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity Journal article Loh N. et al, (2020) Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states. Journal article Liu J. et al, (2019), Biochim Biophys Acta Mol Cell Biol Lipids, 1864 TCF7L2 plays a complex role in human adipose progenitor biology which may contribute to genetic susceptibility to type 2 diabetes Journal article Verma M. et al, (2019) The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study. Journal article Vasan SK. et al, (2019), Diabetologia, 62, 2079 - 2087 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Greig Dougall Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Oliver Featherstone


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267 www.rdm.ox.ac.uk/people/robert-friedrich-donat
268 www.rdm.ox.ac.uk/people/tao-dong
269 www.rdm.ox.ac.uk/people/greig-dougall
270 www.rdm.ox.ac.uk/people/patricia-douglas
271 www.rdm.ox.ac.uk/people/gillian-douglas
272 www.rdm.ox.ac.uk/people/damien-downes
273 www.rdm.ox.ac.uk/people/alexander-drakesmith
274 www.rdm.ox.ac.uk/people/roy-drissen
275 www.rdm.ox.ac.uk/people/edward-drydale
276 www.rdm.ox.ac.uk/people/yue-du
277 www.rdm.ox.ac.uk/people/claire-duff
278 www.rdm.ox.ac.uk/people/samuel-dunkley
279 www.rdm.ox.ac.uk/people/pamela-dyson
280 www.rdm.ox.ac.uk/people/james-early
281 www.rdm.ox.ac.uk/people/james-eaton
282 www.rdm.ox.ac.uk/people/carol-eaton
283 www.rdm.ox.ac.uk/people/laurienne-gardner
284 www.rdm.ox.ac.uk/people/christian-eggeling
285 www.rdm.ox.ac.uk/people/mehroz-ehsan
286 www.rdm.ox.ac.uk/people/jane-ellis
287 www.rdm.ox.ac.uk/people/hanif-esmail
288 www.rdm.ox.ac.uk/people/lise-estcourt
289 www.rdm.ox.ac.uk/people/rachel-etherington
290 www.rdm.ox.ac.uk/people/mark-evans
291 www.rdm.ox.ac.uk/people/tracey-evans
292 www.rdm.ox.ac.uk/people/martyn-ezra
293 www.rdm.ox.ac.uk/people/anne-farmer
294 www.rdm.ox.ac.uk/people/martin-farrall
295 www.rdm.ox.ac.uk/people/oliver-featherstone



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