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Title: Charalambos Antoniades — Radcliffe Department of Medicine
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Texto: Charalambos Antoniades — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Charalambos Antoniades Contact information Email charalambos.antoniades@cardiov.ox.ac.uk Research groups Antoniades Group: The Oxford Translational Cardiovascular Research Group Websites British Heart Foundation Funding body Oxford Heart Vessels and Fat (ox-HVF) cohort Prospective translational programme Cardiovascular Research Journal Reuters video on FAI technology Press DPHIL SUPERVISOR PROFILE Antoniades Group – Translational cardiovascular research: cross-talk between adipose tissue and the cardiovascular system in humans Charalambos Antoniades Professor of Cardiovascular Medicine Deputy Head, Division of Cardiovascular Medicine British Heart Foundation Senior Clinical Fellow Honorary Consultant Cardiologist Crosstalk between adipose tissue and vascular/myocardial redox state in humans: Pharmacological interventions Adipose tissue is now considered to be a “biochemical factory” in the human body, producing a wide range of bioactive molecules, such as adipokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, and may play a critical role in the regulation of redox state and signalling in various tissues, such as the vascular wall and myocardium. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial redox state in atherosclerosis. We also search for novel therapeutic strategies targeting vascular and myocardial redox signalling directly or through changes in the crosstalk between adipose tissue and cardiovascular system . Our group undertakes translational research, moving from bench to bedside and vice versa. We use various clinical research tools, such as non-invasive imaging and others, for the evaluation of vascular / myocardial function. This includes studies on human tissues; we have developed a number of ex vivo models of human tissue (vessels, myocardium and adipose tissue) for translational research, which are complemented by tissue and cell culture techniques. We have also established a large bioresource of human vascular, myocardial and adipose tissue in collaboration with other academic institutions across the world (The Oxford Heart Vessels & Fat (ox-HVF) cohort ) and this is currently being used to support hypothesis driven research in the field of vascular and myocardial redox state regulation. In our lab state-of-the-art techniques are used to visualise and quantify vascular and myocardial free radical production. Using genetic tools to identify patients with pre-specified genetic traits, enables us to apply a “recruit-by-genotype” approach to address biological questions related to the cross-talk between adipose tissue and vascular/myocardial redox signalling in human cardiovascular disease. We are also using state-of-the-art non-invasive imaging techniques (advanced ultrasound and CT imaging techniques) to study the structure and function of the cardiovascular system and explore its interactions with the adipose tissue. This programme of work led to the recent discovery of the "inside-to-outside" signals from the human cardiovascular system to the adipose tissue, and allowed the development of new clinical applications of cardiovascular imaging. Since 2015, the group runs the Oxford Cardiovascular Computed Tomography programme , in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. The group is using artificial intellience and machine learning approaches to analyse radiotranscriptomic signatures that lead to the develpment of new imaging biomarkers. A recent example is that of the develpment of Fat Attenuation Index (FAI), a new biomarker that detects inflammation in the human coronary arteries by analysing the changes of weighed CT attenuation of perivascular adipose tissue (Science Transl Med 2017). FAI has striking predictive value for cardiac mortality and acute coronary events, as demonstrated in a large prospective clinical study (CRISP-CT) organised together with Erlangen University (Germany) and Cleveland Clinic (USA) (Lancet 2018).     Since 2015, the group runs the Oxford Academic cardiovascular Computed Tomography (OXACCT) programme , in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. Within the group, we run the OXACCT Core Lab , peforming advanced analysis of cardiovascular CT images with specific focus on analysis of coronary plaques and perivascular adipose tissue.               Our group also organises small-scale randomised clinical trials that include extensive cardiovascular phenotyping, testing the effects of treatments (statins, folates etc) on the biology of the human vascular wall, myocardium and adipose tissue. Key publications A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Journal article Oikonomou EK. et al, (2019), Eur Heart J, 40, 3529 - 3543 Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Journal article Akoumianakis I. et al, (2019), Sci Transl Med, 11 Imaging residual inflammatory cardiovascular risk. Journal article Antoniades C. et al, (2019), Eur Heart J Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling. Journal article Antoniades C. et al, (2011), Circulation, 124, 335 - 345 Recent publications The Fat Attenuation Index in HIV-infected patients. Journal article West HW. and Antoniades C., (2020), AIDS (London, England), 34, 489 - 490 Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease. Journal article Oikonomou EK. et al, (2020), Cardiovasc Res Acute exposure to diesel affects inflammation and vascular function. Journal article Tousoulis D. et al, (2020), Eur J Prev Cardiol Using Perivascular Fat Attenuation Index to Monitor Coronary Inflammation in Patients With Psoriasis-Reply. Journal article Elnabawi YA. et al, (2020), JAMA Cardiol Scientists on the Spot: non-coding RNAs and heart failure. Journal article Antoniades C. and Condorelli G., (2019), Cardiovasc Res, 115, e164 - e165 Plasma signature of apoptotic microvesicles is associated with endothelial dysfunction and plaque rupture in acute coronary syndromes. Journal article Zacharia E. et al, (2019), J Mol Cell Cardiol A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Journal article Oikonomou EK. et al, (2019), Eur Heart J, 40, 3529 - 3543 Cardiac Computed Tomography: Assessment of Coronary Inflammation and Other Plaque Features. Journal article Oikonomou EK. et al, (2019), Arterioscler Thromb Vasc Biol, 39, 2207 - 2219 Arterial Grafts for Coronary Bypass: A Critical Review After the Publication of ART and RADIAL. Journal article Gaudino M. et al, (2019), Circulation, 140, 1273 - 1284 A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Journal article Douglas G. et al, (2019), Cardiovasc Res More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Carole Bataille Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown


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