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Title: Andrew Armitage — Radcliffe Department of Medicine
Description: M.Biochem, D.Phil Andrew Armitage - Senior Postdoctoral Scientist
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Texto: Andrew Armitage — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Andrew Armitage Contact information Email andrew.armitage@imm.ox.ac.uk Research groups Drakesmith Group: Iron and Immunity Andrew Armitage M.Biochem, D.Phil Senior Postdoctoral Scientist I have worked as a post-doc with Hal Drakesmith since 2008. My work focuses on hepcidin, the hormone that controls how much iron is taken up from the diet and how iron is distributed within the body.   I am firstly interested in how hepcidin is regulated under different physiological circumstances (including infections, iron deficiency and anaemia, and during early childhood), and secondly in how hepcidin-mediated changes in iron status impact upon infections and immunity.     Both mammalian hosts and the pathogens that infect them require iron. A lack of iron can lead to anaemia, yet supplying iron to correct this may exacerbate risk of infections such as malaria. Understanding the interplay between iron handling, anaemia and infections is therefore important, and hepcidin plays a central role.   To study the hepcidin-iron axis, we carry out experiments using in vitro and murine models besides performing studies in humans, notably through our collaboration with the MRC Gambia Unit.   Over recent years, we have investigated the behaviour of hepcidin during several human infections (such as typhoid, HIV-1, and malaria) and evaluated what hepcidin can tell us about the iron status of children in low-income countries. We have developed a mouse model in which hepcidin deletion can be induced, which is useful for studying the role of hepcidin in infections.   We have also helped translate our laboratory experience of hepcidin measurement to the Clinical Biochemistry department in the John Radcliffe Hospital.   I previously studied Biochemistry in Oxford, before carrying out my DPhil in the MRC Human Immunology Unit (HIU), supervised by Astrid Iversen and Andrew McMichael. My project evaluated whether APOBEC3 anti-HIV restriction factors, which are capable of extensively editing viral genomes, are likely to contribute to HIV-1 diversification.   Beyond our specific research group, I also perform other roles:   I run the monthly Unit-wide HIU Immunology Breakfast journal club series that facilitates discussion of recent high profile developments in immunology. I manage and maintain the QuantStudio7 qRT-PCR instrumentation for the MRC HIU. I am Co-Chair of the WIMM Post-Doc Association, which provides support for post-docs as they progress in their careers and aims to promote a friendly collaborative ethos within the WIMM. I provide tutorials in Immunology to Oxford 3rd year Biochemistry students. Recent publications Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia. Journal article Arezes J. et al, (2020), Blood, 135, 547 - 557 Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia. Journal article Bah A. et al, (2019), Lancet Glob Health, 7, e1564 - e1574 Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. Journal article Gooding S. et al, (2019), Nat Commun, 10 Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge Journal article Williams AM. et al, (2019), The American Journal of Clinical Nutrition The Diagnostic Potential of the Iron-Regulatory Hormone Hepcidin Journal article ARMITAGE A. and DRAKESMITH A., (2019), Hemasphere More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Charalambos Antoniades Alex Antonopoulos Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Charlotte Brierley Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark Crabtree Fay Croft Heidi Crook Eloise Cross Nicholas Crump Andres Hueso Cuervo Nicola Curry Melinda Czéh Liangti Dai Andrea van Dam Rinita Dam Matt Daniels Lorna Daniels Carol Davey James Davies Graham Davies Simon Davis James Dean Rebecca Dean Atanasiu Stefan Demian Niall Dempster Louise Dennis Timothy Dent Geoffrey Denwood Michael Desborough Matthew Dickinson Marina Diotallevi Tomasz Dobrzycki Cameron Dockerill Michael Dodd Kathleen Dolan Hamid Dolatshad Robert Friedrich Donat Tao Dong Greig Dougall Patricia Douglas Gillian Douglas Damien Downes Hal Drakesmith Roy Drissen Edward Drydale Yue Du Claire Duff Sam Dunkley Pamela Dyson James Early James Eaton Carol Eaton Laurienne Edgar Christian Eggeling Mehroz Ehsan Jane Ellis Hanif Esmail Lise Estcourt Rachel Etherington Mark Evans Tracey Evans Martyn Ezra Anne Farmer Martin Farrall Oliver Featherstone Martin Fellermeyer Candida Fenton David Ferguson João Ferreira Fernandes


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258 www.rdm.ox.ac.uk/people/matthew-dickinson
259 www.rdm.ox.ac.uk/people/marina-diotallevi
260 www.rdm.ox.ac.uk/people/tomasz-dobrzycki
261 www.rdm.ox.ac.uk/people/cameron-dockerill
262 www.rdm.ox.ac.uk/people/michael-dodd
263 www.rdm.ox.ac.uk/people/kathleen-dolan
264 www.rdm.ox.ac.uk/people/hamid-dolatshad
265 www.rdm.ox.ac.uk/people/robert-friedrich-donat
266 www.rdm.ox.ac.uk/people/tao-dong
267 www.rdm.ox.ac.uk/people/greig-dougall
268 www.rdm.ox.ac.uk/people/patricia-douglas
269 www.rdm.ox.ac.uk/people/gillian-douglas
270 www.rdm.ox.ac.uk/people/damien-downes
271 www.rdm.ox.ac.uk/people/alexander-drakesmith
272 www.rdm.ox.ac.uk/people/roy-drissen
273 www.rdm.ox.ac.uk/people/edward-drydale
274 www.rdm.ox.ac.uk/people/yue-du
275 www.rdm.ox.ac.uk/people/claire-duff
276 www.rdm.ox.ac.uk/people/samuel-dunkley
277 www.rdm.ox.ac.uk/people/pamela-dyson
278 www.rdm.ox.ac.uk/people/james-early
279 www.rdm.ox.ac.uk/people/james-eaton
280 www.rdm.ox.ac.uk/people/carol-eaton
281 www.rdm.ox.ac.uk/people/laurienne-gardner
282 www.rdm.ox.ac.uk/people/christian-eggeling
283 www.rdm.ox.ac.uk/people/mehroz-ehsan
284 www.rdm.ox.ac.uk/people/jane-ellis
285 www.rdm.ox.ac.uk/people/hanif-esmail
286 www.rdm.ox.ac.uk/people/lise-estcourt
287 www.rdm.ox.ac.uk/people/rachel-etherington
288 www.rdm.ox.ac.uk/people/mark-evans
289 www.rdm.ox.ac.uk/people/tracey-evans
290 www.rdm.ox.ac.uk/people/martyn-ezra
291 www.rdm.ox.ac.uk/people/anne-farmer
292 www.rdm.ox.ac.uk/people/martin-farrall
293 www.rdm.ox.ac.uk/people/oliver-featherstone
294 www.rdm.ox.ac.uk/people/martin-fellermeyer
295 www.rdm.ox.ac.uk/people/candida-fenton
296 www.rdm.ox.ac.uk/people/david-ferguson
297 www.rdm.ox.ac.uk/people/joao-ferreira-fernandes



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