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Title: Adam Braithwaite — Radcliffe Department of Medicine
Description: BSc (hons.), MRes Adam Braithwaite - Postdoctoral Researcher
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Texto: Adam Braithwaite — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search People Adam Braithwaite Contact information Email adam.braithwaite@cardiov.ox.ac.uk ORCID https://orcid.org/0000-0003-3228-2172 Research groups Choudhury Group: Understanding Inflammatory processes in Atherosclerosis and Acute Myocardial Infarction Social media Adam Braithwaite BSc (hons.), MRes Postdoctoral Researcher Mechanisms of trained immunity in diabetic macrophages and atherosclerosis As a Postdoctoral Researcher in Professor Robin Choudhury's group, I am investigating the mechanisms by which hyperglycaemia leads to epigenetic reprogramming of bone marrow stems cells and a persistent pro-inflammatory, pro-atherosclerotic phenotype. Cardiovascular events and atherosclerosis are a leading cause of death in patients with diabetes, even after blood glucose levels are reduced by pharmacological intervention. A key effect of hyperglycaemia is the reprogramming of myeloid cells to a pro-inflammatory phenotype, which persists after hyperglycaemia is corrected. However, the mechanisms of this reprogramming remain to be fully elucidated. I obtained my BSc in Medical Microbiology at the University of Leeds, including a 1-year internship researching the genetics of neurodegenerative diseases at the Mayo Clinic, Jacksonville FL.  I went on to carry out research and complete an MRes at Imperial College London, exploring the molecular causes of cardiovascular diseases including cardiomyopathy and hypertension. I then undertook Doctoral research training at the University of Sheffield, specialising in pulmonary vascular disease. My PhD thesis aimed to elucidate the divergent roles of the cytokine TRAIL in pulmonary arterial hypertension and pulmonary fibrosis. In 2019 I moved to the University of Oxford to pursue further cardiovascular research as a Novo Nordisk Foundation-funded Postdoctoral scientist. Key publications A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Journal article Arnold ND. et al, (2019), Nature communications, 10 Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension. Journal article Farkas D. et al, (2019), Am J Respir Crit Care Med, 199, 199 - 210 Divergent Roles for TRAIL in Lung Diseases. Journal article Braithwaite AT. et al, (2018), Front Med (Lausanne), 5 Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension. Journal article Boehm M. et al, (2018), BMC Pulm Med, 18 Selective improvement of pulmonary arterial hypertension with a dual ETA/ETB receptors antagonist in the apolipoprotein E-/- model of PAH and atherosclerosis. Journal article Renshall L. et al, (2018), Pulm Circ, 8 CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients. Journal article Horswell SD. et al, (2013), J Lipid Res, 54, 3491 - 3505 Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Journal article McDermott-Roe C. et al, (2011), Nature, 478, 114 - 118 Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Journal article Winner B. et al, (2011), Neurobiol Dis, 41, 706 - 716 Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Journal article Melrose HL. et al, (2010), Neurobiol Dis, 40, 503 - 517 In vivo silencing of alpha-synuclein using naked siRNA. Journal article Lewis J. et al, (2008), Mol Neurodegener, 3 Genomic investigation of alpha-synuclein multiplication and parkinsonism. Journal article Ross OA. et al, (2008), Ann Neurol, 63, 743 - 750 More publications © 2020 Radcliffe Department of Medicine Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Our Divisions Investigative Medicine Division Nuffield Division of Clinical Laboratory Sciences Oxford Centre for Diabetes, Endocrinology and Metabolism Division of Cardiovascular Medicine MRC Weatherall Institute of Molecular Medicine MRC Weatherall Institute of Molecular Medicine Our Clinical Facilities and MRC Units Acute Vascular Imaging Centre Cardiovascular Clinical Research Facility Oxford Centre for Clinical Magnetic Resonance Research Working at RDM Equal career opportunities and flexible working Career development and training Athena SWAN News Seminars Locations and contact details Research Cardiovascular Science Haematology and Pathology Diabetes, Metabolism and Endocrinology Cancer Biology Immunology and Infection Stem Cells and Developmental Biology Geratology Experimental Therapeutics Ashrafian Group: Experimental Therapeutics and Clinical Pharmacology Mahmod group Tyler Group Lunter Group: Functional Genomics & Machine Learning Lunter Group Chapman Group: Genome stability and DNA repair mechanisms in cancer and genome diversification Patel Group People Moustafa Abdalla Ines Abdesselam Adib Abdullah Amanda Adler Satish Adwani Devika Agarwal Olorunsola Agbaje Doaa Ahmed Jila Ajeian Nadia Akawi Naveed Akbar Nasren Akhtar Ioannis Akoumianakis Merve Aksoz Marta Perez Alcantara Yara Alenazi Affaf Aliouat Jack Allen Maryam Alsharqi Sneha Anand Amanda Anderson Agata Antepowicz Charalambos Antoniades Alex Antonopoulos Mahesh Appari Andrew Apps Janhavi Apte Rina Ariga Andrew Armitage Alyssa Armsby Linda Arnold Ritu Arya James Ashford Neil Ashley Nicole Ashman Houman Ashrafian Kate Attfield Christian Babbs Mohsin Badat Ileana Badi Jade Bailey Subita Balaram Abhirup Banerjee Alison Banham Adrian Banning Liliana Barbieri Mike Barnkob Amy Barrett Matthew Baxter Asha Bayliss Robert Beagrie Daniel Beard Jordan Becker John Bell John Bell Elena Benedetto Amanda Bennett Felicity Bennett Timothy Betts Ryan Beveridge Shoumo Bhattacharya William Biggs Malenka Bissell Edward Blair Henry Blest Nicholas Blockley Henry Boardman Andrea Borghetto Alessandra Borlotti Jacqueline Boultwood Yavor Bozhilov Adam Braithwaite Robert Brand Matt Brechin Serena Briant Linford Briant Anne Bridgeman Paul Brodersen James Brown Jill Brown Lynn Brown Connor Broyles Marella de Bruijn Alastair Buchan Veronica Buckle Paul Buckley Daniel Bulte Martijn van de Bunt Mario Buono Holger Burchert Emma Burke-Smith Oliver Burns Matthew Burrage Shijie Cai David Cain Sarah Califano Ivan Candido-Ferreira Fang Cao Maria Carena Maria Carena Ricardo Carnicer Davide Carone Joana Carrelha Brigid Carter Barbara Casadei Carla Cascone Kuan Cha Hedia Chagraoui Jem Chalk Keith Channon Ross Chapman Lise Chauveau Jane Cheeseman Yi-Ling Chen Jili Chen Qian Cheng Amy Chiu Robin Choudhury Constantinos Christodoulides Zoe Christodoulou Sandy Chu Surawee Chuaiphichai Aldo Ciau-Uitz Thomas Clague Sally-Ann Clark Kevin Clark Lynn Clee Liz Cloke Christopher Cole Ruth Coleman Huw Colin-York Michela Colombo Ismael da Conceicao Catriona Conway Daniel Cooke Kerrie Cope Anna Corby Thomas Cornfield Eduardo Calpena Corpas Yvonne Couch Mark


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