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Texto: Antoniades Group: The Oxford Translational Cardiovascular Research Group — Radcliffe Department of Medicine Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us About us Our Divisions Our Clinical Facilities and MRC Units Working at RDM Athena SWAN News Seminars Locations and contact details Research People Study with us Work with us Current vacancies Novo Nordisk - Oxford Fellowships For Staff Contacts, travel and maps Personnel Finance, Grants and Funding Facilities, IT and Health and Safety Graduate Studies Career Development Athena SWAN Communications and public engagement Search About us Our Divisions Division of Cardiovascular Medicine Research in the Division of Cardiovascular Medicine Antoniades Group: The Oxford Translational Cardiovascular Research Group Antoniades Group: The Oxford Translational Cardiovascular Research Group charalambos.antoniades@cardiov.ox.ac.uk Division of Cardiovascular Medicine Our group studies the interplay between adipose tissue and the cardiovascular system. Using translational approaches, we develop novel diagnostic tools for the early detection of cardiovascular diseases and risk stratification. We also work towards the discovery of new therapeutic targets for the prevention and treatment of cardiovascular diseases, in the context of obesity and diabetes. There are three main bodies of research undertaken by our group: Studying the interplay between adipose tissue and the cardiovascular system Adipose tissue is now considered to be a ‘biochemical factory’ in the human body, producing a wide range of bioactive molecules, such as adipokines and adipocytokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, playing a critical role in cardiovascular disease pathogenesis. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial disease pathogenesis, with specific focus on changes in redox-sensitive inflammatory mechanisms. Read more Translational Research in the group Our group undertakes translational research, moving from bench to bedside and vice versa. We have established one of the world’s most extensively phenotyped cohorts of patients undergoing cardiac surgery, The Oxford Heart Vessels & Fat (ox-HVF) cohort. The cohort includes more than 1500 patients undergoing cardiac surgery, who have been extensively phenotyped preoperatively using non-invasive imaging. Read more T he Oxford Cardiovascular Computed Tomography Programme Since 2015, the group runs the Oxford Cardiovascular Computed Tomography Programme, in partnership with the Manor Hospital and Oxford University Hospitals NHS Foundation Trust, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. The programme includes translational cardiovascular CT imaging, supported by expertise in Artificial Intelligence and machine learning. The Oxford Academic Cardiovascular CT (OXACCT) core lab operates within the programme, and provides state-of-the-art advanced cardiovascular CT image analysis services, to academic and industrial studies.  Read more Our team Charalambos Antoniades Professor of Cardiovascular Medicine Nadia Akawi Postdoctoral Researcher Alex Antonopoulos Visiting Postdoctoral Clinical Researcher Sheena Thomas Technical Lead - OXACCT Core Lab / Specialist cardiac CT radiographer Henry West DPhil Student Christos Kotanidis DPhil Candidate Ileana Badi Senior Postdoctoral Researcher Elsa Mauricio Reus Clinical Researcher Murray Polkinghorne DPhil Student Maria Lyasheva Clinical Researcher Laura Klüner DPhil Student Muhammad Siddique Senior Postdoctoral Researcher Nigar Syed Research Radiographer Evangelos K. Oikonomou DPhil Student Tracey Evans Research Radiographer Ioannis Akoumianakis Research Associate, Division of Cardiovascular Medicine DPHIL SUPERVISOR PROFILE Translational cardiovascular research: cross-talk between adipose tissue and the cardiovascular system in humans Find out more Reuters coverage of Professor Antoniades work Professor Antoniades group has developed a new method for analysing CT scan images can predict who is at risk of a heart attack - years before it happens. Find out more Selected publications Uncovering the skeleton in the heart: an unusual case of mitral annular calcification extending to the left ventricular myocardium. Journal article Nikolaidou C. et al, (2020), Eur Heart J Cardiovasc Imaging Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction. Journal article Meakin PJ. et al, (2020), J Clin Invest Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition. Journal article Akoumianakis I. et al, (2020), Sci Transl Med, 12 The use of multiparametric 18F-fluoro-L-3,4-dihydroxy-phenylalanine PET/MRI in post-therapy assessment of patients with gliomas. Journal article Fraioli F. et al, (2020), Nucl Med Commun The Fat Attenuation Index in HIV-infected patients. Journal article West HW. and Antoniades C., (2020), AIDS (London, England), 34, 489 - 490 Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease. Journal article Oikonomou EK. et al, (2020), Cardiovasc Res Acute exposure to diesel affects inflammation and vascular function. Journal article Tousoulis D. et al, (2020), Eur J Prev Cardiol Molecular imaging to guide precision diagnosis and prevention of cancer therapeutics-related cardiac dysfunction. Journal article Oikonomou EK., (2020), Expert Rev Mol Diagn, 1 - 4 Using Perivascular Fat Attenuation Index to Monitor Coronary Inflammation in Patients With Psoriasis-Reply. Journal article Elnabawi YA. et al, (2020), JAMA Cardiol Highlights of AHA Scientific Sessions 2019: novel approaches in cardiovascular risk reduction. Journal article Akoumianakis I., (2020), Cardiovasc Res, 116, e16 - e18 Free full text Free full text for selected papers: Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases: Full text Reprint Collaborators Professor Dimitris Tousoulis, University of Athens, Greece Prof David Lefer, LSU School of Medicine, New Orleans, USA Prof Alison Noble, University of Oxford, UK Prof Keith M Channon, University of Oxford, UK Dr Milind Desai MD, Cleveland Clinic, USA Professor Pál Maurovich-Horvat MD, MPH, PhD, Semmelweis University, Hungary  Prof Stephan Achenbach, University of Erlangen, Germany Funding The British Heart Foundation Innovate UK


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41 mailto:charalambos.antoniades@cardiov.ox.ac.uk
42 http://www.oxhvf.com
43 www.rdm.ox.ac.uk/about/our-divisions/division-of-cardiovascular-medicine/division-of-cardiovascular-medicine-research/the-oxford-translational-cardiovascular-research-group/studying-the-interplay-between-adipose-tissue-and-the-cardiovascular-system
44 www.rdm.ox.ac.uk/about/our-divisions/division-of-cardiovascular-medicine/division-of-cardiovascular-medicine-research/the-oxford-translational-cardiovascular-research-group/translational-research-in-the-group
45 www.rdm.ox.ac.uk/about/our-divisions/division-of-cardiovascular-medicine/division-of-cardiovascular-medicine-research/the-oxford-translational-cardiovascular-research-group/the-oxford-cardiovascular-computed-tomography-programme
46 www.rdm.ox.ac.uk/people/charalambos-antoniades
47 www.rdm.ox.ac.uk/people/nadia-akawi
48 www.rdm.ox.ac.uk/people/alexios-antonopoulos
49 www.rdm.ox.ac.uk/people/sheena-thomas
50 www.rdm.ox.ac.uk/people/henry-west
51 www.rdm.ox.ac.uk/people/christos-kotanidis
52 www.rdm.ox.ac.uk/people/ileana-badi
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54 www.rdm.ox.ac.uk/people/murray-polkinghorne
55 www.rdm.ox.ac.uk/people/maria-lyasheva
56 www.rdm.ox.ac.uk/people/laura-kluner
57 www.rdm.ox.ac.uk/people/muhammad-siddique
58 www.rdm.ox.ac.uk/people/nigar-syed
59 www.rdm.ox.ac.uk/people/evangelos-oikonomou
60 www.rdm.ox.ac.uk/people/tracey-evans
61 www.rdm.ox.ac.uk/people/ioannis-akoumianakis
62 www.rdm.ox.ac.uk/study-with-us/supervisor-profiles-2020/antoniades-group
63 https://www.reuters.com/article/us-health-heart-britain/tech-breakthrough-offers-early-warning-system-for-heart-attacks-idUSKCN1ME14F
64 www.rdm.ox.ac.uk/publications/1105669/modal
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74 http://stm.sciencemag.org/cgi/content/full/11/510/eaav5055?ijkey=ndc4Qrcv/BTQw&keytype=ref&siteid=scitransmed
75 https://stm.sciencemag.org/content/11/510/eaav5055.full?ijkey=ndc4Qrcv/BTQw&keytype=ref&siteid=scitransmed
76 https://stm.sciencemag.org/content/scitransmed/11/510/eaav5055.full.pdf?ijkey=ndc4Qrcv/BTQw&keytype=ref&siteid=scitransmed
77 www.medschool.lsuhsc.edu/cardio_center/contact_us_lefer.aspx
78 www.ibme.ox.ac.uk/research/biomedia/people/professor-alison-noble
79 www.rdm.ox.ac.uk/people/keith-channon
80 https://my.clevelandclinic.org/staff/6670-milind-desai
81 http://vszek.semmelweis.hu/maurovich-horvat-pal-md
82 https://www.bhf.org.uk/
83 www.gov.uk/government/organisations/innovate-uk



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