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Date: Mon, 18 Nov 2019 08:46:44 GMT
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Title: Rebeccah Slater — Department of Paediatrics
Description: PhD MSc BSc ARSM Rebeccah Slater - Professor of Paediatric Neuroscience
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Texto: Rebeccah Slater — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Rebeccah Slater Contact information Email rebeccah.slater@paediatrics.ox.ac.uk Telephone 01865 234 229 Biography   Rebeccah Slater is Professor of Paediatric Neuroscience and a Senior Wellcome Trust Research Fellow. She is also a Professorial Fellow at St John's College. Rebeccah studied Physics (BSc) at Imperial College and Neuroscience (MSc) at UCL, and in 2007 was awarded her PhD at UCL under the supervision of Prof Maria Fitzgerald. Since 2013 she has led the Paediatric Neuroimaging Research Group, which focuses on understanding the mechanisms that underlie the development of pain perception in the human infant. She uses a range of non-invasive brain imaging tools, including EEG and fMRI, to explore the development of pain perception in the human nervous system. She has published many articles about infant pain and has been passionately involved in science communication and the public engagement of science. She has taken part in numerous discussions on TV and radio, including BBC Radio 4 and the BBC World Service. Rebeccah holds an honorary research position in the Neonatal Care Services at the John Radcliffe Children’s Hospital and is a PI at the Wellcome Centre for Integrative Neuroimaging (WIN).  Find out more about the Poppi Trial   - a Randomised Controlled Trial investigating the analgesic efficacy of morphine in premature infants. Rebeccah Slater PhD MSc BSc ARSM Professor of Paediatric Neuroscience Senior Wellcome Trust Research Fellow Understanding the mechanisms that drive the development of pain perception in the human infant My Research Pain in infancy has negative long-term consequences and its prevention is a clinical priority, but adequate treatment requires mechanistic understanding of the structural and functional development of human nociceptive circuitry. My research group aims to understand the mechanisms that drive and modulate pain perception in early human development. Recent scientific advances provide insights into how noxious information is transmitted to the infant brain, providing a platform to ask how intrinsic brain network connectivity and the environment affect noxious-evoked brain activity, behaviour and ultimately pain perception in the developing infant nervous system. We are investigating whether inherent differences in how the brain behaves at rest influence variability in noxious-evoked activity, and will determine how this relationship is altered by environmental factors and pathology. We want to understand how the development of structural and functional network connectivity alters noxious-evoked brain activity, and influences the dynamic relationship between brain activity and behaviour. The overarching goal is that this developmental understanding will  translate into the improved treatment of infant pain in premature and term-born infants.   Key publications Nociceptive brain activity as a measure of analgesic efficacy in infants. Journal article Hartley C. et al, (2017), Sci Transl Med, 9 Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development. Journal article Hartley C. et al, (2016), Curr Biol, 26, 1998 - 2002 fMRI reveals neural activity overlap between adult and infant pain. Journal article Goksan S. et al, (2015), Elife, 4 Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. Journal article Slater R. et al, (2010), Lancet, 376, 1225 - 1232 Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial. Journal article Hartley C. et al, (2018), Lancet, 392, 2595 - 2605 Recent publications Multimodal pain assessment improves discrimination between noxious and non‐noxious stimuli in infants Journal article Vaart M. et al, (2019), Paediatric and Neonatal Pain A tool for functional brain imaging with lifetime compliance Journal article Hill R. et al, (2019), Nature Communications Nociception and the neonatal brain. Journal article Gursul D. et al, (2019), Semin Fetal Neonatal Med The challenge of distinguishing pain from distress in young children. Journal article Slater R., (2019), Lancet Child Adolesc Health Birth experience in newborn infants is associated with changes in nociceptive sensitivity. Journal article Kasser S. et al, (2019), Sci Rep, 9 More publications Websites Google Scholar Scopus Researchgate © 2019 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement


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