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Title: Philip Goulder — Department of Paediatrics
Description: MA FRCPCH DPhil FMedSci Philip Goulder - Professor of Immunology
Texto: Philip Goulder — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Philip Goulder Contact information Email Telephone 01865 281884 PA Kathryn Southey Read our study in Science Translational Medicine  here . The study shows that one in ten children with HIV do not develop Aids because their immune system 'ignores' the virus. Check out the 'In the news' section on our group page for interviews and articles about this work. My Connections HIV Research Group Brasenose College Biography Philip Goulder is Professor of Immunology at Oxford University. He is also Honorary Professor at the University of KwaZulu-Natal in South Africa, and holds Honorary Consultant Paediatric appointments at the John Radcliffe Hospital in Oxford and in the Department of Infectious Disease at Great Ormond St Hospital for Children, London. He is a Fellow at Brasenose College Oxford. He obtained his first degree in Zoology at Oxford University in 1982, and then qualified in Medicine at Cambridge University in 1986, before completing training in Paediatrics through appointments at Edinburgh, Oxford, Duke University Medical Center in the US and the Royal Hospital for Sick Children in Melbourne, Australia. His investigative career started in 1993, undertaking a DPhil under the supervision of Andrew McMichael, followed by a post-doc, with appointments at Boston Children’s Hospital and Harvard Medical School, working under the mentorship of Bruce Walker. His research group is based at The Peter Medawar Building in Oxford. The focus of this work is the African HIV epidemic. To this end, he leads research groups in Durban and Kimberley, having established long-standing collaborations in South Africa, cofounding the UKZN HIV Pathogenesis Programme in 1998. Goulder is a Research Associate at CAPRISA (Centre for the AIDS Programme of Research in South Africa), AHRI (The Africa Health Research Institute) and the Ragon Institute of MGH, MIT and Harvard. He received an Elizabeth Glaser Paediatric AIDS Foundation Scientist Award in 1999, a Wellcome Trust Senior Clinical Fellowship from 2002-2015 and a Wellcome Trust Investigator Award in 2015.  Philip Goulder MA FRCPCH DPhil FMedSci Professor of Immunology My aim is to identify interventions that reduce disease in HIV infection and explore the potential for a cure in infected children. The overarching goal of my research is to identify interventional approaches that will reduce disease in HIV infection, and to explore the particular potential for HIV cure in infected children. My work has sought to define the role of CTL escape in immune control of HIV, the impact of escape mutations on viral replicative capacity, the principal mechanisms of HLA-mediated control of HIV, and the evolutionary aspects of the epidemic. Our key publications in these areas are listed on the right.  A particular interest of our work is the paediatric HIV epidemic. Children are highly vulnerable to HIV infection and yet at the same time present unique opportunities to understand mechanisms of HIV disease and the potential for HIV cure. Interventional studies we have led include the first early ART (anti-retroviral therapy) initiation studies in HIV-infected newborn infants in Africa, and a first-in-man Phase I clinical trial testing peptide immunotherapy to augment T-cell responses. More recently, in July 2015, we have started a ‘Baby Cure’ study in KwaZulu-Natal, South Africa, in which babies who are HIV-infected in utero are diagnosed and ART initiated within hours of birth. The goal of this study is to minimize the latent viral reservoirs in these children, paving the way for subsequent further interventions to eradicate HIV infection entirely. A major focus of our current work is a group of HIV-infected children aged >5yrs who have never received ART and yet who appear entirely healthy, and indistinguishable in terms of CD4 counts and immune function from age-matched HIV-uninfected children. Unlike the adult ‘elite controllers’, who suppress viral replication via HLA-mediated mechanisms, these paediatric ‘non-progressors’ maintain normal immunity in the face of persistent high viral loads. Understanding the genetic, immune and virologic mechanisms underlying this phenotype is critical to defining novel approaches to minimise HIV disease.   Funding Sources Goulder has received funding from the Wellcome Trust from 2002-2015 through Senior Clinical Fellowships and since 2015 through a Wellcome Trust Investigator Award, 2015-2020. He has also received RO1 support from the National Institutes of Health since 2000 (most recent RO1 award from 2017-2022). In press Goulder PJR and Deeks SG. HIV control: Is getting there the same as staying there? PLoS Pathogens, 2018 Key publications Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape. Journal article Leitman EM. et al, (2017), The Journal of Experimental Medicine, 214, 3239 - 3261 Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. Journal article Muenchhoff M. et al, (2016), Science translational medicine, 8, 358ra125 - 358ra125 Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection. Journal article Adland E. et al, (2015), PLoS Pathog, 11 Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence. Journal article Payne R. et al, (2014), Proc Natl Acad Sci U S A, 111, E5393 - E5400 Sex differences in pediatric infectious diseases. Journal article Muenchhoff M. and Goulder PJR., (2014), J Infect Dis, 209 Suppl 3, S120 - S126 HIV and HLA class I: an evolving relationship. Journal article Goulder PJR. and Walker BD., (2012), Immunity, 37, 426 - 440 The impact of differential antiviral immunity in children and adults. Journal article Prendergast AJ. et al, (2012), Nat Rev Immunol, 12, 636 - 648 Adaptation of HIV-1 to human leukocyte antigen class I. Journal article Kawashima Y. et al, (2009), Nature, 458, 641 - 645 CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Journal article Kiepiela P. et al, (2007), Nat Med, 13, 46 - 53 Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Journal article Kiepiela P. et al, (2004), Nature, 432, 769 - 775 Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. Journal article Draenert R. et al, (2004), J Exp Med, 199, 905 - 915 HIV evolution: CTL escape mutation and reversion after transmission. Journal article Leslie AJ. et al, (2004), Nat Med, 10, 282 - 289 Evolution and transmission of stable CTL escape mutations in HIV infection. Journal article Goulder PJ. et al, (2001), Nature, 412, 334 - 338 P07-07. Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+ specific T cell responses over time Journal article Prado JG. et al, (2009), Retrovirology, 6 Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Journal article Goulder PJ. et al, (1997), Nat Med, 3, 212 - 217 © 2019 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement

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