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Texto: Matthew Wood — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Matthew Wood Contact information Email matthew.wood@paediatrics.ox.ac.uk Telephone 01865 272419 01865 282840 PA Louise Gillane mjaw-pa@paediatrics.ox.ac.uk Research groups Wood Group Matthew Wood Professor of Neuroscience Matthew Wood graduated in Medicine from the University of Cape Town in 1987, working in clinical Neuroscience before gaining a doctorate in Physiological Sciences from the University of Oxford in 1993.  He is currently University Lecturer, and Fellow and Tutor in Medicine and Physiology at Somerville College. Matthew’s research is in field of gene therapy for degenerative disorders of the nervous system and muscle. The main focus is the investigation of novel therapeutic approaches utilising short nucleic acids to target messenger RNA. Targeting RNA has the potential to allow modification of the target transcript, reprogramming of endogenous genetic defects or the targeting of specific disease alleles, all the while maintaining endogenous regulation of the target gene. Current work is investigating the potential of single-stranded antisense oligonucleotides for the modification of mRNA splicing, for example in Duchenne muscular dystrophy. In addition, the potential of double-stranded RNA for gene silencing, known as RNA interference (RNAi), is being investigated for the silencing of target genes and mutant alleles both in muscle and in the nervous system. In particular, RNAi has great potential as a future therapeutic agent for currently untreatable neurodegenerative disorders such as Parkinson’s disease. Key publications Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Journal article Alvarez-Erviti L. et al, (2011), Nat Biotechnol, 29, 341 - 345 Recent publications Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice. Journal article Ahlskog N. et al, (2020), Gene Ther Publisher Correction: A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. Journal article de Jong OG. et al, (2020), Nat Commun, 11 A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. Journal article de Jong OG. et al, (2020), Nat Commun, 11 Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) and AAV-U7 rescues the severe DMD phenotype in mice Journal article WOOD MJ. et al, (2020), Molecular Therapy - Methods and Clinical Development MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles. Journal article Osorio-Querejeta I. et al, (2020), Pharmaceutics, 12 More publications © 2020 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Contact Us Funding our research A history of paediatrics at Oxford Learn more about our research Alumni News EUCLIDS Study investigates responses to Meningitis B vaccination Noxious Stimulation in Children Receiving General Anaesthesia Evokes an Increase in Delta Frequency Brain Activity Oxford Vaccine Group in Oxford MedSci News Oxford Vaccine Group launches Paratyphoid study Meningitis B Vaccine recommended for introduction into UK schedule OVG Typhoid study volunteers interviewed by the BBC Hitting the top spot for student satisfaction Innovation in good health at Oxford University Hospital Medical School Prize winners announced Athena SWAN awards for nine University departments Professor Irene Roberts appointed NIHR Theme Lead Dr. Eleni Louka awarded NIHR Fellowship OSOP presents: Careers in Paediatrics OSOP Presents: Working in Child Protection Pop-up Science pulls in the public Centre for Clinical Vaccinology and Tropical Medicine 10th Anniversary HIV Research Group receive major Wellcome Trust award £18.5m to train future bioscience leaders Oxford ranked number 1 for Clinical, Pre-Clinical and Health-related subjects Calling the shots - OMSG Article New vaccine generates strong immune response against hepatitis C From the Minds of Babes: New Frontiers in Paediatric Pain Research suggests ability of HIV to cause AIDS is slowing Oxford Medical Sciences excels in REF 2014 exercise Thinking Postgraduate? Think Oxford Oxford Vaccine Group begins first trial of new Ebola vaccine NIHR Oxford Biomedical Research Centre Open Weeks 2015 OSOP Presents: Bridging the gap between primary and secondary care services for children Oxford secures £139m in HEFCE research funding Investigating Meningococcal Vaccines in Adults Babies feel pain ‘like adults’ Fundraising campaign reaches £2 billion - and counting Professor Louise Richardson nominated as next Vice-Chancellor Professor of Paediatrics successfully defends her PhD 80 years later than originally planned Participate in our new Ebola study Oxford Ebola vaccine study moves to next phase Towards the prevention of RSV: A major cause of infant death Very premature and underweight babies are at risk of growing up as neurotic adults Vaccines Against Salmonella Typhi: Call for Participants Vaccine for common childhood infection may finally be possible Vaccine Knowledge App Graduate courses now open for 2016/17 Ebola Medals for Research Team Prestigious NIHR grant awarded to Rebeccah Slater Care 24/7: Making the clinical handover safe Applications open for the D.Phil in Infection, Immunology, and Translational Medicine Volunteers sought for study into vaccine for serious childhood infection Understanding the genetic basis for immune responses to flu vaccines in children and adults Nepal Earthquake - Experiences from our colleagues Dr Manish Sadaranganis wins Communications Prize at the Academy of Medical Sciences Nepal research has lessons for global vaccination efforts New Vice-Chancellor pledges ‘innovative, creative’ future for Oxford Oxford Experimental Psychology - Experimental Psychology mourns the sudden death of Professor Glyn Humphreys Andrew Pollard has been awarded a Principal Fellowship by the Oxford Biomedical Research Centre Why Mark Zuckerberg was right to vaccinate his daughter What is meningitis B – and why don’t older children get the vaccine? Dr Matthew Snape on 'Pikin to Pikin Tok' Measles and the MMR Vaccine Children with cancer given hope of having a family in the future Would you like your child to be vaccinated against chickenpox? Future of Oxford Chair in Developmental Medicine secured with £3.3million gift Would you like to help develop new typhoid vaccines? Partnership announces publication of positive phase 1 data for Ebola vaccine regimen It’s World Immunisation Week! Herd Immunity: How does it work? We need more nurses! Graduate Scholarship in Paediatrics Soapbox Science Dr Matthew Snape wins prize for engaging the public Neonatologist Dominic Wilkinson has been made Professor Georg Hollander and Andrew Pollard join the Fellowship of the Academy of Medical Sciences Everything you need to know about chickenpox and why more countries don’t use the vaccine Babies' painkiller problem Study suggests routes to improved immunity in older people Children could point the way to new HIV treatments Going Viral An international consortium, which includes the Department's Oxford Vaccine Group Receives $36.9 Million Grant to Fight Typhoid World Pneumonia Day: Making vaccines work to prevent pneumonia When art and science meet World AIDS Day 2016 University of Oxford launches Public Engagement with Research Strategic Plan Marta Valente Pinto receives Public Engagement Award from the University Oxford Science Blog-Detecting Counterfeit Medicines Brain Diaries: infant pain BBC: Would you trial an Ebola vaccine? 'Two-part Ebola vaccine offers long-lasting protection' Rebeccah Slater Nominated to World Economic Forum The Conversation: 'How is Europe doing on immunisation coverage?' Watch: Videos from OVG Immunisation Seminars 2017 Using pain-related brain activity to improve pain relief in infants Paediatrics takes part in Living Well Oxford Oxford Vaccine Group win OxTALENT Awards The Conversation: What's behind the sudden rise in measles deaths in Europe? Researchers at the Department of Paediatrics Highly Commended in PER Awards BBC Radio 4: Hepatitis B vaccine added to childhood national programme The Guardian: 'Small decline in MMR vaccination rates could have dramatic effect, experts warn' Dr Rebeccah Slater secures Wellcome Senior Research Fellowship Introducing Eugene Duff: New SSNAP Fellow in Paediatric Neuroscience Curiosity Carnival comes to Oxford 'New technology could allow multiple vaccines to be delivered in single jab' New typhoid vaccine offers hope of protection for children Introduction of pneumococcal vaccine in Nepal having impact Winners at the Thames Valley Health Research Awards OVG at the Curiosity Carnival Paediatrics welcomes new starters Introducing Michelle van Velthoven: new Sir David Cooksey Fellow in Healthcare Translation Snowy department Christmas celebration bma-contribution-to-paediatrics-research-project Mildred Iro wins best paediatrics paper of 2017! Anti-vaxxer effect on vaccination rates is exaggerated Medical Sciences heads to the Big Bang Fair Oxford Vaccine Group leads meningitis vaccine trial for teenagers Launching a typhoid vaccine study in Nepal How do vaccines work? Rebeccah Slater at the Pint of Science festival International Clinical Trials Day at the Children's Hospital Cheltenham Science Festival: Let’s talk about infant


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