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Respuesta: HTTP/1.1 200 OK
Date: Wed, 13 Nov 2019 02:18:51 GMT
Server: Zope/(2.13.22, python 2.7.12, linux2) ZServer/1.1
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URL: https://www.paediatrics.ox.ac.uk/team/matthew-wood
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Title: Matthew Wood — Department of Paediatrics
Description: Matthew Wood - Professor of Neuroscience
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Texto: Matthew Wood — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Matthew Wood Contact information Email matthew.wood@paediatrics.ox.ac.uk Telephone 01865 272419 01865 282840 PA Louise Gillane mjaw-pa@paediatrics.ox.ac.uk Research groups Wood Group Matthew Wood Professor of Neuroscience Matthew Wood graduated in Medicine from the University of Cape Town in 1987, working in clinical Neuroscience before gaining a doctorate in Physiological Sciences from the University of Oxford in 1993.  He is currently University Lecturer, and Fellow and Tutor in Medicine and Physiology at Somerville College. Matthew’s research is in field of gene therapy for degenerative disorders of the nervous system and muscle. The main focus is the investigation of novel therapeutic approaches utilising short nucleic acids to target messenger RNA. Targeting RNA has the potential to allow modification of the target transcript, reprogramming of endogenous genetic defects or the targeting of specific disease alleles, all the while maintaining endogenous regulation of the target gene. Current work is investigating the potential of single-stranded antisense oligonucleotides for the modification of mRNA splicing, for example in Duchenne muscular dystrophy. In addition, the potential of double-stranded RNA for gene silencing, known as RNA interference (RNAi), is being investigated for the silencing of target genes and mutant alleles both in muscle and in the nervous system. In particular, RNAi has great potential as a future therapeutic agent for currently untreatable neurodegenerative disorders such as Parkinson’s disease. Key publications Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Journal article Alvarez-Erviti L. et al, (2011), Nat Biotechnol, 29, 341 - 345 Recent publications Wrangling RNA: Antisense oligonucleotides for neurological disorders Journal article Talbot K. and Wood MJA., (2019), Science Translational Medicine, 11, eaay2069 - eaay2069 Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice. Journal article Klein AF. et al, (2019), J Clin Invest Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases. Journal article Tsoumpra MK. et al, (2019), EBioMedicine, 45, 630 - 645 The viral protein corona directs viral pathogenesis and amyloid aggregation. Journal article Ezzat K. et al, (2019), Nat Commun, 10 Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics. Journal article Coenen-Stass AML. et al, (2019), RNA Biol, 16, 696 - 706 More publications © 2019 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement


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