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Title: Holm Uhlig — Department of Paediatrics
Description: Holm Uhlig - Professor of Paediatric Gastroenterology, Group Head / PI and Hon Consultant Physician
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Texto: Holm Uhlig — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Site Map Accessibility Cookies Contact us Log in Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Holm Uhlig Holm Uhlig Contact information Email holm.uhlig@ndm.ox.ac.uk Research groups Mucosal Immunology Holm Uhlig Professor of Paediatric Gastroenterology, Group Head / PI and Hon Consultant Physician The gastrointestinal immune system has evolved to avoid and counteract the invasion of pathogens. To allow a strong inflammatory immune response during infection but avoid tissue damage there is a need for effective immune regulation. Defects in immune regulation lead to immunopathology such as inflammatory bowel disease (IBD). About one fifth of all patients with IBD present with initial symptoms during childhood and adolescents. In particular in the very young children patients an underlying immunodeficiency may cause IBD-like symptoms. The analysis of immune deviation in children with IBD and IBD-like symptoms may contribute to the understanding of the complex puzzle of molecular mechanisms involved in IBD. To investigate novel genetic defects using next generation sequencing und perform functional analysis of the immunological consequences. A key focus of our group is the understanding how genetic defects in macrophages cause defective bacterial handling and inflammation.  Recent publications Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. Journal article Béziat V. et al, (2020), J Exp Med, 217 COVID-19 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto group of ESPGHAN. Journal article Turner D. et al, (2020), J Pediatr Gastroenterol Nutr Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome. Journal article Chen Y-H. et al, (2020), J Exp Med, 217 Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease. Journal article Serra EG. et al, (2020), Nat Commun, 11 Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a Single Center. Journal article Crowley E. et al, (2020), Gastroenterology More publications © 2020 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement Site Map Accessibility Cookies Contact us Log in About us Contact Us Funding our research A history of paediatrics at Oxford Learn more about our research Alumni News EUCLIDS Study investigates responses to Meningitis B vaccination Noxious Stimulation in Children Receiving General Anaesthesia Evokes an Increase in Delta Frequency Brain Activity Oxford Vaccine Group in Oxford MedSci News Oxford Vaccine Group launches Paratyphoid study Meningitis B Vaccine recommended for introduction into UK schedule OVG Typhoid study volunteers interviewed by the BBC Hitting the top spot for student satisfaction Innovation in good health at Oxford University Hospital Medical School Prize winners announced Athena SWAN awards for nine University departments Professor Irene Roberts appointed NIHR Theme Lead Dr. Eleni Louka awarded NIHR Fellowship OSOP presents: Careers in Paediatrics OSOP Presents: Working in Child Protection Pop-up Science pulls in the public Centre for Clinical Vaccinology and Tropical Medicine 10th Anniversary HIV Research Group receive major Wellcome Trust award £18.5m to train future bioscience leaders Oxford ranked number 1 for Clinical, Pre-Clinical and Health-related subjects Calling the shots - OMSG Article New vaccine generates strong immune response against hepatitis C From the Minds of Babes: New Frontiers in Paediatric Pain Research suggests ability of HIV to cause AIDS is slowing Oxford Medical Sciences excels in REF 2014 exercise Thinking Postgraduate? Think Oxford Oxford Vaccine Group begins first trial of new Ebola vaccine NIHR Oxford Biomedical Research Centre Open Weeks 2015 OSOP Presents: Bridging the gap between primary and secondary care services for children Oxford secures £139m in HEFCE research funding Investigating Meningococcal Vaccines in Adults Babies feel pain ‘like adults’ Fundraising campaign reaches £2 billion - and counting Professor Louise Richardson nominated as next Vice-Chancellor Professor of Paediatrics successfully defends her PhD 80 years later than originally planned Participate in our new Ebola study Oxford Ebola vaccine study moves to next phase Towards the prevention of RSV: A major cause of infant death Very premature and underweight babies are at risk of growing up as neurotic adults Vaccines Against Salmonella Typhi: Call for Participants Vaccine for common childhood infection may finally be possible Vaccine Knowledge App Graduate courses now open for 2016/17 Ebola Medals for Research Team Prestigious NIHR grant awarded to Rebeccah Slater Care 24/7: Making the clinical handover safe Applications open for the D.Phil in Infection, Immunology, and Translational Medicine Volunteers sought for study into vaccine for serious childhood infection Understanding the genetic basis for immune responses to flu vaccines in children and adults Nepal Earthquake - Experiences from our colleagues Dr Manish Sadaranganis wins Communications Prize at the Academy of Medical Sciences Nepal research has lessons for global vaccination efforts New Vice-Chancellor pledges ‘innovative, creative’ future for Oxford Oxford Experimental Psychology - Experimental Psychology mourns the sudden death of Professor Glyn Humphreys Andrew Pollard has been awarded a Principal Fellowship by the Oxford Biomedical Research Centre Why Mark Zuckerberg was right to vaccinate his daughter What is meningitis B – and why don’t older children get the vaccine? Dr Matthew Snape on 'Pikin to Pikin Tok' Measles and the MMR Vaccine Children with cancer given hope of having a family in the future Would you like your child to be vaccinated against chickenpox? Future of Oxford Chair in Developmental Medicine secured with £3.3million gift Would you like to help develop new typhoid vaccines? Partnership announces publication of positive phase 1 data for Ebola vaccine regimen It’s World Immunisation Week! Herd Immunity: How does it work? We need more nurses! Graduate Scholarship in Paediatrics Soapbox Science Dr Matthew Snape wins prize for engaging the public Neonatologist Dominic Wilkinson has been made Professor Georg Hollander and Andrew Pollard join the Fellowship of the Academy of Medical Sciences Everything you need to know about chickenpox and why more countries don’t use the vaccine Babies' painkiller problem Study suggests routes to improved immunity in older people Children could point the way to new HIV treatments Going Viral An international consortium, which includes the Department's Oxford Vaccine Group Receives $36.9 Million Grant to Fight Typhoid World Pneumonia Day: Making vaccines work to prevent pneumonia When art and science meet World AIDS Day 2016 University of Oxford launches Public Engagement with Research Strategic Plan Marta Valente Pinto receives Public Engagement Award from the University Oxford Science Blog-Detecting Counterfeit Medicines Brain Diaries: infant pain BBC: Would you trial an Ebola vaccine? 'Two-part Ebola vaccine offers long-lasting protection' Rebeccah Slater Nominated to World Economic Forum The Conversation: 'How is Europe doing on immunisation coverage?' Watch: Videos from OVG Immunisation Seminars 2017 Using pain-related brain activity to improve pain relief in infants Paediatrics takes part in Living Well Oxford Oxford Vaccine Group win OxTALENT Awards The Conversation: What's behind the sudden rise in measles deaths in Europe? Researchers at the Department of Paediatrics Highly Commended in PER Awards BBC Radio 4: Hepatitis B vaccine added to childhood national programme The Guardian: 'Small decline in MMR vaccination rates could have dramatic effect, experts warn' Dr Rebeccah Slater secures Wellcome Senior Research Fellowship Introducing Eugene Duff: New SSNAP Fellow in Paediatric Neuroscience Curiosity Carnival comes to Oxford 'New technology could allow multiple vaccines to be delivered in single jab' New typhoid vaccine offers hope of protection for children Introduction of pneumococcal vaccine in Nepal having impact Winners at the Thames Valley Health Research Awards OVG at the Curiosity Carnival Paediatrics welcomes new starters Introducing Michelle van Velthoven: new Sir David Cooksey Fellow in Healthcare Translation Snowy department Christmas celebration bma-contribution-to-paediatrics-research-project Mildred Iro wins best paediatrics paper of 2017! Anti-vaxxer effect on vaccination rates is exaggerated Medical Sciences heads to the Big Bang Fair Oxford Vaccine Group leads meningitis vaccine trial for teenagers Launching a typhoid vaccine study in Nepal How do vaccines work? Rebeccah Slater at the Pint of Science festival International Clinical Trials Day at the Children's Hospital Cheltenham Science Festival: Let’s talk about infant pain! New guidelines to monitor blood cancer in Down syndrome babies OxTalent recognition for the Paediatric Neuroimaging team!


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