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Respuesta: HTTP/1.1 200 OK
Date: Wed, 13 Nov 2019 03:10:38 GMT
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URL: https://www.paediatrics.ox.ac.uk/team/holm-uhlig
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Title: Holm Uhlig — Department of Paediatrics
Description: Holm Uhlig - Professor of Paediatric Gastroenterology, Group Head / PI and Hon Consultant Physician
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Texto: Holm Uhlig — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Holm Uhlig Holm Uhlig Contact information Email holm.uhlig@ndm.ox.ac.uk Research groups Mucosal Immunology Holm Uhlig Professor of Paediatric Gastroenterology, Group Head / PI and Hon Consultant Physician The gastrointestinal immune system has evolved to avoid and counteract the invasion of pathogens. To allow a strong inflammatory immune response during infection but avoid tissue damage there is a need for effective immune regulation. Defects in immune regulation lead to immunopathology such as inflammatory bowel disease (IBD). About one fifth of all patients with IBD present with initial symptoms during childhood and adolescents. In particular in the very young children patients an underlying immunodeficiency may cause IBD-like symptoms. The analysis of immune deviation in children with IBD and IBD-like symptoms may contribute to the understanding of the complex puzzle of molecular mechanisms involved in IBD. To investigate novel genetic defects using next generation sequencing und perform functional analysis of the immunological consequences. A key focus of our group is the understanding how genetic defects in macrophages cause defective bacterial handling and inflammation.  Recent publications The Role of PTEN in Innate and Adaptive Immunity. Journal article Taylor H. et al, (2019), Cold Spring Harb Perspect Med Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23 Internet publication ASCHENBRENNER D. et al, (2019) Remission of inflammatory bowel disease in Glucose-6-Phosphatase 3 deficiency by allogeneic haematopoietic stem cell transplantation. Journal article Bolton C. et al, (2019), J Crohns Colitis Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ. Journal article Swan DJ. et al, (2019), Haematologica The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages Journal article Schulthess J. et al, (2019), Immunity More publications © 2019 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement


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