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Date: Mon, 18 Nov 2019 08:49:41 GMT
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Title: Caroline Hartley — Department of Paediatrics
Description: MMath MRes PhD Caroline Hartley - Wellcome Trust/Royal Society Sir Henry Dale Fellow
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Texto: Caroline Hartley — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Caroline Hartley Contact information Email caroline.hartley@paediatrics.ox.ac.uk Telephone 01865 234537 Research groups Paediatric Neuroimaging Biography Caroline is a Sir Henry Dale Fellow funded by the Wellcome Trust and Royal Society. Caroline completed her undergraduate degree in Mathematics at the University of Warwick in 2008. She then joined the Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, first undertaking a Master's degree in Mathematical Biology before carrying on to do a PhD. Her PhD research examined brain development in preterm babies, looking at EEG recordings and using computational neural network models to explore how neuronal connections form in the developing brain. Caroline then moved to the University of Oxford, working as a Postdoctoral Researcher with Prof. Rebeccah Slater. As part of this work, Caroline developed methods to assess analgesic efficacy in infants using noxious-evoked brain activity, and led the Poppi (Procedural Pain in Premature Infants) Clinical Trial investigating the analgesic efficacy and safety of morphine in premature infants. In 2018, Caroline was awarded a Sir Henry Dale Fellowship to investigate the impact of apnoea on brain development in premature infants. Caroline Hartley MMath MRes PhD Wellcome Trust/Royal Society Sir Henry Dale Fellow Caroline's research focuses on understanding the impact of apnoea on premature infant brain development. Apnoea - the cessation of breathing - is a common pathology associated with prematurity. These potentially life-threatening events can result in reduced cerebral oxygenation and frequent episodes of apnoea have been associated with long-term effects including reduced childhood cognitive ability. 1 in every 10 babies are born prematurely; understanding and mitigating the long-term impact of premature birth is important to improve the lives of these children. Caroline develops approaches to analyse infant brain activity and physiological data, such as heart rate and oxygen saturation, to address clinically relevant questions in the field of neonatal neuroscience. Key publications Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial. Journal article Hartley C. et al, (2018), Lancet, 392, 2595 - 2605 Nociceptive brain activity as a measure of analgesic efficacy in infants. Journal article Hartley C. et al, (2017), Sci Transl Med, 9 Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development. Journal article Hartley C. et al, (2016), Curr Biol, 26, 1998 - 2002 fMRI reveals neural activity overlap between adult and infant pain. Journal article Goksan S. et al, (2015), Elife, 4 Recent publications Multimodal pain assessment improves discrimination between noxious and non‐noxious stimuli in infants Journal article Vaart M. et al, (2019), Paediatric and Neonatal Pain A tool for functional brain imaging with lifetime compliance Journal article Hill R. et al, (2019), Nature Communications Nociception and the neonatal brain. Journal article Gursul D. et al, (2019), Semin Fetal Neonatal Med Birth experience in newborn infants is associated with changes in nociceptive sensitivity. Journal article Kasser S. et al, (2019), Sci Rep, 9 A universal right to pain relief: balancing the risks in a vulnerable patient population. Journal article Moultrie F. et al, (2019), Lancet Child Adolesc Health, 3, 62 - 64 More publications © 2019 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement


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