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Date: Wed, 13 Nov 2019 01:48:11 GMT
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Title: Anindita Roy — Department of Paediatrics
Description: MRCPCH FRCPath PhD Anindita Roy - Associate Professor of Paediatric Haematology
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Texto: Anindita Roy — Department of Paediatrics Cookies on this website We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings. Continue Find out more Skip to main content Site Map Accessibility Cookies Contact us Log in Menu Home About us News Events Research Recent publications Study with us Work with Us Our team Search Our team Anindita Roy Contact information Email anindita.roy@paediatrics.ox.ac.uk Telephone +44 (0)1865 222419 Research groups Childhood Leukaemia Research Group Developmental Haematology and Paediatric Leukaemia Group Websites Follow me on Twitter Anindita Roy MRCPCH FRCPath PhD Associate Professor of Paediatric Haematology Wellcome Trust Clinician Scientist in Paediatric Haematology Honorary Clinical Lecturer in Paediatric Haematology, Great Ormond Street Hospital, London Main research interest: understanding the origins and biology of childhood leukaemia. The main focus of my research is to study prenatal B lymphopoiesis in order to understand the origins of childhood leukaemia, in particular infant acute lymphoblastic leukaemia (ALL). Prenatal B lymphopoiesis is different from adult B cell development; and developmentally-regulated characteristics of fetal B-progenitors are likely to provide the 'oncogenic' cellular context necessary to co-operate with MLL rearrangements to induce infant ALL.  We have recently defined the B lymphoid developmental hierarchy before birth, and my research aims to identify the target cell population for leukaemia initiation in infant ALL. Characterisation of the target cell by molecular and functional assays, including developmental differences when compared to postnatal cells, will allow us to identify specific pathways that can be targeted for future therapies. I am also a member of Prof Irene Roberts’ team investigating how trisomy 21 perturbs haematopoiesis before birth and its implications for Down syndrome associated leukaemias in children. Previous academic placements: LLR Clinical Training Fellowship (2007-2011) and NIHR Academic Clinical Lectureship in Paediatric Haematology (2011-2015) at Imperial College London. During my placement at Imperial College, I worked primarily on characterising fetal haematopoiesis and understanding how it is perturbed by trisomy 21. Bloodwise Clinician Scientist (2015-2019) at University of Oxford. Key publications Decoding human fetal liver haematopoiesis. Journal article Popescu D-M. et al, (2019), Nature Discovery of a CD10 negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs. Journal article O'Byrne S. et al, (2019), Blood MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. Journal article Kerry J. et al, (2017), Cell Rep, 18, 482 - 495 High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans. Journal article Roy A. et al, (2017), Clinical immunology (Orlando, Fla.), 183, 8 - 16 GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia. Journal article Roberts I. et al, (2013), Blood, 122, 3908 - 3917 Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Journal article Roy A. et al, (2012), Proc Natl Acad Sci U S A, 109, 17579 - 17584 Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations. Journal article Tunstall-Pedoe O. et al, (2008), Blood, 112, 4507 - 4511 Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways Journal article Psaila B. et al, Genome Biology Recent publications Single cell analysis of bone marrow derived CD34+ cells from children with sickle cell disease and thalassemia. Journal article Hua P. et al, (2019), Blood Decoding human fetal liver haematopoiesis. Journal article Popescu D-M. et al, (2019), Nature Discovery of a CD10 negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs. Journal article O'Byrne S. et al, (2019), Blood Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation. Journal article Abdulhay NJ. et al, (2019), J Exp Med Unravelling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis. Journal article Agraz-Doblas A. et al, (2019), Haematologica Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia Conference paper Louka E. et al, (2017), BLOOD, 130 More publications © 2019 University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU Freedom of Information Privacy Policy Copyright Statement Accessibility Statement


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